mA modification of AC026356.1 facilitates hepatocellular carcinoma progression by regulating the IGF2BP1-IL11 axis.

N-methyladenosine (mA) is the most common RNA modification in eukaryotic RNAs. Although the important roles of mA in RNA fate have been revealed, the potential contribution of mA to RNA function in various diseases, including hepatocellular carcinoma (HCC), is still unclear. In this study, we identified a novel mA-modified RNA AC026356.

Serum gamma-glutamyltransferase within its normal range predicts a chronic elevation of alanine aminotransferase: a four year follow-up study.

Background: Previous epidemiological and experimental studies support the concept that serum gamma-glutamyltransferase (GGT) activity within its normal range is related to oxidative stress. Since oxidative stress plays a crucial role in the pathogenesis of various liver diseases, serum GGT may predict development of liver damage.

Methods: A total of 6,523 healthy male workers with normal alanine aminotransferase (ALT, <35 U/l) in a steel manufacturing company were followed for four years.