Publications by authors named "Jinhoo Song"
Therapeutic potential of anti-ErbB3 chimeric antigen receptor natural killer cells against breast cancer.
Cancer Immunol Immunother
January 2025
ErbB3 is markedly overexpressed in breast cancer cells and is associated with resistance and metastasis. Additionally, ErbB3 expression levels are positively correlated with low densities of tumor-infiltrating lymphocytes, a marker of poor prognosis. Consequently, ErbB3 is a promising therapeutic target for cancer immunotherapy.
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- Head and neck squamous cell carcinoma (HNSCC) has poor survival rates and current treatments are highly toxic, creating a demand for new therapies that can effectively target cancer cells.
- The study explored the combination of radiotherapy, cetuximab, and expanded natural killer (NK) cells to enhance treatment efficacy, showing that radiation increases sensitivity of tumors to NK cells and cetuximab.
- Results revealed that this combination significantly suppressed cancer progression and improved survival, although adding PD-1 inhibitors did not provide extra benefit, indicating a promising new therapy for HNSCC.
Background: RNA-binding proteins (RBPs) perform various biological functions in humans and are associated with several diseases, including cancer. Therefore, RBPs have emerged as novel therapeutic targets. Although recent investigations have shown that RBPs have crucial functions in breast cancer (BC), detailed research is underway to determine the RBPs that are closely related to cancers.
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