Effects of TLR9/NF-κB on oxidative stress and inflammation in IPEC-J2 cells.

Background: Oxidative stress is one of the most important factors affecting large-scale breeding, especially the performance of pigs. Oxidative stress plays a role by affecting various genes in pigs, which can cause serious body damage, functional degradation and reduce production performance.

Objective: The purpose of this study was to investigate the effect of Toll like receptor 9 (TLR9) pathway on IPEC-J2 cells under oxidative stress and to provide reference for the growth development of Dapulian pigs.

Two New 3D Supramolecular Complexes: Photocatalytic Properties and Treatment Activity for Gastric Cancer.

Two new coordination polymers, [Cu₂(5-MeO-Hip)₄(py)₄] () and [Co(5-EtO-ip)(4,4'-bipy)]·n(MeOH) () (5-MeO-H₂ip is 5-methoxyisophthalic acid, 5-EtO-H₂ip is 5-ethoxyisophthalic acid, py is pyridine, and 4,4'-bipy is 4,4'-bipyridine), were created via solvothermal self-assembly. The thermal steadiness and photocatalytic functions of and were detected, and their application values in gastric cancer and the related mechanism were discussed. CCK-8 assay was used to determine the inhibitory activity toward gastric cancer cells' viability, and real-time RT-PCR was employed to examine the gastric cancer cells' Notch signaling pathway activity.

Role of gene in PRRSV infection of PAM cells.

Background: Interferon lambda receptor 1 () is a type II cytokine receptor that clings to interleukins IL-28A, IL29B, and IL-29 referred to as type III IFNs (IFN-λs). IFN-λs act through the JAK-STAT signaling pathway to exert antiviral effects related to preventing and curing an infection. Although the immune function of IFN-λs in virus invasion has been described, the molecular mechanism of IFNLR1 in that process is unclear.

Effect of bevacizumab combined with docetaxel in the treatment of HER-2-negative recurrent metastatic breast cancer.

Purpose: To explore the efficacy and safety of bevacizumab combined with docetaxel in the treatment of human epidermal growth factor receptor-2 (HER-2)-negative recurrent metastatic breast cancer.

Methods: The clinical data of 128 patients with HER-2-negative recurrent metastatic breast cancer treated in our hospital from January 2015 to December 2016 were retrospectively analyzed. Sixty-four patients were treated with bevacizumab combined with docetaxel (Bevacizumab group), while the remaining 64 patients were treated with docetaxel alone (Docetaxel group).

[Construction of miR-331-3p overexpression vector and its effect on cell proliferation].

To investigate the effect of miR-331-3p on the proliferation of porcine renal epithelial cells (PK15) and its mechanism, the pcDNA 3.1(+) overexpression vector of miRNA-331-3p (pcDNA 3.1(+)-miR-331-3p) was constructed.