A Double-Side CMOS-CNT Biosensor Array With Padless Structure for Simple Bare-Die Measurements in a Medical Environment.

This paper presents a double-side CMOS-carbon nanotube (CNT) sensor array for simple bare-die measurements in a medical environment based on a 0.35 μm standard CMOS process. This scheme allows robust measurements due to its inherent back-side rectifying diodes with a high latch-up resistance.

Modulation of molecular hybridization and charge screening in a carbon nanotube network channel using the electrical pulse method.

In this paper, we investigate the effect of electrical pulse bias on DNA hybridization events in a biosensor platform, using a Carbon Nanotube Network (CNN) and Gold Nano Particles (GNP) as an electrical channel. The scheme provides both hybridization rate enhancement of bio molecules, and electrical measurement in a transient state to avoid the charge screening effect, thereby significantly improving the sensitivity. As an example, the probe DNA molecules oscillate with pulse trains, resulting in the enhancement of DNA hybridization efficiency, and accordingly of the sensor performances in Tris-EDTA (TE) buffer solution, by as much as over three times, compared to the non-biasing conditions.

Comparative analysis of electrical detection methods of DNA synthesis.

The incorporation of a complementary deoxynucleotide (dNTP) into a self-primed single-stranded DNA (ssDNA) attached to the surface of a sensor electrode generates an H+ charge that can be either trapped on the sensor surface or diffused into the surrounding solution. Electrical detection methods of DNA synthesis are based on these H+ kinetic mechanisms. The detection method that uses ISFET, which is related to the surface trapping mechanism, showed a better sensing signal than the induced charge detection method, which is related to the diffusion of H+ into the surrounding solution.

Multi-order dynamic range DNA sensor using a gold decorated SWCNT random network.

A novel electrical DNA biosensor is presented, which consists of gold (Au) nanoscale islands and a single-walled carbon nanotube (SWCNT) network on top of a concentric Au electrode array (also referred to as the CGi). The decorated Au islands on the SWCNT network provide ideal docking sites for ss-DNA probe (p-DNA) molecules. They also provide better adhesion between the SWCNT network and the chip substrate.