Publications by authors named "Jinho Park"

Background: Nucleated red blood cells (nRBCs) are increased by disease processes and hematopoietic stress.

Objectives: To evaluate the utility of nRBCs as a marker of disease severity and prognosis in dogs with systemic inflammatory response syndrome (SIRS).

Animals: Sixty-two client-owned dogs met the criteria of SIRS without anemia.

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Background: Bone defects are commonly encountered due to accidents, diseases, or aging, and the demand for effective bone regeneration, particularly for dental implants, is increasing in our aging society. Mesenchymal stem cells (MSCs) are promising candidates for regenerative therapies; however, obtaining sufficient quantities of these cells for clinical applications remains challenging. DW-MSCs, derived from embryonic stem cells and developed by Daewoong Pharmaceutical, exhibit a robust proliferative capacity even after extensive culture.

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Osteoporosis is a common skeletal disease, primarily associated with aging, that results from decreased bone density and bone volume. This reduction significantly increases the risk of fractures in osteoporosis patients compared to individuals with normal bone density. Additionally, the bone regeneration process in these patients is slow, making complete healing difficult.

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Poor placental development and placental defects can lead to adverse pregnancy outcomes such as pre-eclampsia, fetal growth restriction, and stillbirth. This study introduces two sensors, which use a near-infrared spectroscopy (NIRS) technique to measure placental oxygen saturation transabdominally. The first one, an NIRS sensor, is a wearable device consisting of multiple NIRS channels.

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Background: Lumbar spinal stenosis (LSS) is prevalent among octogenarians, causing significant pain and disability. Surgical intervention is often required because of the ineffectiveness of conservative treatments. This study investigates the efficacy and safety of biportal endoscopic decompressive laminectomy (BED) in octogenarians with severe LSS, evaluating its potential as a minimally invasive surgical option.

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Background And Objectives: Several studies have explored strategies to prevent proximal junctional kyphosis (PJK) which is the unresolved issue in adult spinal deformity (ASD) surgery. This study aimed to investigate the preventive effects of upper instrumented vertebrae (UIV) recombinant human bone morphogenetic protein-2 (rhBMP-2) with beta-tricalcium phosphate (β-TCP) carrier injection on PJK.

Methods: This study was conducted through a retrospective analysis of data collected both prospectively and retrospectively.

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  • Infection with tick-borne pathogens in cattle can lead to serious health issues like anemia and growth retardation.
  • This study tested both housed and grazing cattle in Korea for the presence of specific pathogens using antigen tests and analyzed antibody levels.
  • The results indicated that while both types of cattle had similar antibody detection rates for one pathogen, grazing cattle had significantly higher antibody levels for the other pathogen, highlighting the distinct exposure risks associated with their environments.
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  • * Researchers created liver-specific CAR knockout (KO) mice to explore CAR's role in the liver; although body weight didn't change, KO mice on a high-fat diet experienced more liver damage, inflammation, and lipid build-up compared to wild-type mice.
  • * The study identified a novel relationship between CAR and a protein called APOBEC3C, suggesting that CAR regulates lipid accumulation by affecting APOBEC3C levels
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Bovine hemolytic anemia has a negative impact on animal welfare and productivity due to its associated clinical symptoms. Hemolysis is generally known to cause reticulocytosis, increased indirect bilirubin, decreased concentration of haptoglobin, and increased lactate dehydrogenase. Additionally, tissue hypoperfusion due to concomitant anemia increases blood lactate concentration.

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Background: Calf diarrhea leads to high mortality rates and decreases in growth and productivity, causing negative effects on the livestock industry. Lactate is closely associated with metabolic acidosis in diarrheic calves. However, there have been no reports on lactate concentrations in Korean indigenous (Hanwoo) calves, especially those with diarrhea.

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A two-stream convolutional neural network (TCNN) for breathing pattern classification has been devised for the continuous monitoring of patients with infectious respiratory diseases. The TCNN consists of a convolutional neural network (CNN)-based autoencoder and classifier. The encoder of the autoencoder generates deep compressed feature maps, which contain the most important information constituting data.

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Development of efficient portable sensors for accurately detecting biomarkers is crucial for early disease diagnosis, yet remains a significant challenge. To address this need, we introduce the enhanced luminescence lateral-flow assay, which leverages highly luminescent upconverting nanoparticles (UCNPs) alongside a portable reader and a smartphone app. The sensor's efficiency and versatility were shown for kidney health monitoring as a proof of concept.

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High-performance electromagnetic interference (EMI) shielding materials with high flexibility, low density, and hydrophobic surface are crucial for modern integrated electronics and telecommunication systems in advanced industries like aerospace, military, artificial intelligence, and wearable electronics. In this study, we present flexible and hydrophobic MXene/Ni-coated polyester (PET) fabrics featuring a double-layered structure, fabricated via a facile and scalable dip-dry coating process followed by electroless nickel plating. Increasing the dip-dry coating iterations up to 10 cycles boosts the MXene loading content (∼31 wt %) and electrical conductivity (∼86 S/cm) of MXene-coated PET fabrics, while maintaining constant porosity (∼95%).

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Dermatophytic pseudomycetoma (DPM), which is a deeper dermal and/or subcutaneous infection of dermatophytes, has been rarely reported in Domestic Korean Short Hair Cats. A 3-year-old, spayed female, domestic Korean Short Hair Cat presented with a history of crusts, nodules, and pruritus for 1 year. At the initial presentation, multifocal ulcerative nodules covered with yellowish grains were noted on her ventral thorax, abdomen, flank, and left hindlimb.

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Omphalitis, commonly caused by opportunistic bacteria has been significantly associated with morbidity and mortality in neonatal calves. is a commensal and opportunistic pathogen that can cause suppurative infection in farm animals. Our case involved a 10-day-old female Korean indigenous calf that presented with umbilical enlargement accompanied by a greenish-yellow purulent discharge and right forelimb lameness.

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Bovine coronavirus (BCoV) is a pneumoenteric virus that can infect the digestive and respiratory tracts of cattle, resulting in economic losses. Despite its significance, information regarding BCoV pathogenesis is limited. Hence, we investigated clinical signs, patterns of viral shedding, changes in antibody abundance, and cytokine/chemokine production in calves inoculated with BCoV via intranasal and oral.

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The metal ion transporter SLC39A8 is associated with physiological traits and diseases, including blood manganese (Mn) levels and inflammatory bowel diseases (IBD). The mechanisms by which SLC39A8 controls Mn homeostasis and epithelial integrity remain elusive. Here, we generate Slc39a8 intestinal epithelial cell-specific-knockout (Slc39a8-IEC KO) mice, which display markedly decreased Mn levels in blood and most organs.

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  • The study addresses the challenge of distinguishing solid nodules from ground-glass lesions in lung cancer, particularly for tumors smaller than or equal to 2 cm, due to high variability in human assessments.
  • It utilizes artificial intelligence (AI) to analyze and classify these nodules from a dataset of 246 patients, aiming to improve the accuracy of preoperative assessments by correlating AI findings with pathological results.
  • The AI system successfully identified solid nodules with high confidence that were associated with a significant likelihood of malignancy and lymph node metastasis, suggesting that this approach could enhance surgical decision-making for lung cancer patients.
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Most currently available wearable devices to noninvasively detect hypoxia use the spatially resolved spectroscopy (SRS) method to calculate cerebral tissue oxygen saturation (StO). This study applies the single source-detector separation (SSDS) algorithm to calculate StO. Near-infrared spectroscopy (NIRS) data were collected from 26 healthy adult volunteers during a breath-holding task using a wearable NIRS device, which included two source-detector separations (SDSs).

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Background: Patients with Lumbar Spinal Stenosis (LSS) typically complain of back pain and leg pain. These symptoms reduce the quality of life (QoL) and also cause sleep disturbances. This study compares pregabalin and limaprost's efficacy in LSS for pain, disability, QoL, and sleep, aiming to offer insights for medication selection.

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  • The study aimed to compare the blood profiles of Hanwoo cattle raised in barns versus those grazing outdoors.
  • Significant differences were found, with grazing cattle showing lower levels of hematocrit, hemoglobin, and red blood cells, indicating potential regenerative anemia.
  • Additionally, higher indirect bilirubin levels in grazing cattle suggested intravascular hemolysis, along with neutropenia and monocytosis being detected.
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Background: No tick-borne pathogens (TBPs) causing haemolytic anaemia in cattle have been reported, except Theileria orientalis and complete blood count (CBC) profile is the only haematological parameter to determine the severity of regenerative haemolytic anaemia.

Objectives: To identify the causative agents of TBP-induced haemolytic anaemia and determine haematological parameters that indicate haemolytic anaemia in grazing cattle.

Methods: Eighty-two Korean indigenous cattle (Hanwoo) were divided into two groups: grazing (n = 67) and indoor (n = 15) groups.

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  • Hemotropic mycoplasmas, specifically Mycoplasma wenyonii and Candidatus Mycoplasma haemobos, cause bovine hemoplasmosis, but their presence in Korean native cattle was previously unstudied.
  • In a study involving 104 cattle, a 34% prevalence of hemoplasmas was found, with M. wenyonii being more common than C. M. haemobos, which was restricted to grazing cattle.
  • Although some differences in red blood cell parameters were observed in C. M. haemobos-infected cattle, the study found no significant link between hemoplasma infection and anemia, highlighting the need for further research into these infections' implications.
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  • * 25 patients received the injection, while 75 controls underwent traditional surgery; results showed significantly lower PJK and PJF rates in the treatment group.
  • * CT scans indicated increased bone formation at the UIV after 6 months in the rhBMP-2 group, suggesting that this method supports new bone growth and improves surgical outcomes.
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The development of a non-invasive method to analyze cytokine expression in the skin will provide further understanding of inflammatory skin disorders. This study aimed to evaluate cytokine expression in the skin through cerumen swabbing in dogs with otitis externa (OE) and to investigate whether increased cytokine expression in infected OE reflects the inflammatory status of the ear canal. Three groups consisting of control dogs ( = 24), dogs with ceruminous OE ( = 25), and dogs with suppurative bacterial OE ( = 15) were included in the study.

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