Enhanced Predefined-Time Control for Spacecraft Attitude Tracking: A Dynamic Predictive Approach.

This study presents a predefined-time control strategy for rigid spacecraft, employing dynamic predictive techniques to achieve robust and precise attitude tracking within predefined time constraints. Advanced predictive algorithms are used to effectively mitigate system uncertainties and environmental disturbances. The main contributions of this work are introducing adaptive global optimization for period updates, which relaxes the original restrictive conditions; ensuring easier parameter adjustments in predefined-time control, providing a nonconservative upper bound on system stability; and developing a continuous, robust control law through terminal sliding mode control and predictive methods.

Preparation and Performance Evolution of Plasma Sprayed Abradable CuAl/PHB-NiAl Layered Seal Coatings.

In this study, a double-layered CuAl/PHB-NiAl seal coating was prepared on a GH4169 substrate by atmospheric plasma spraying. The evolution of the microstructure and mechanical properties of the coating under simulated working conditions was studied. The surface hardness of as-sprayed coating decreased with an increase in the temperature from 25 to 700 °C, decreasing from 90.

Transcription factor Sp1 is upregulated by PKCι to drive the expression of YAP1 during pancreatic carcinogenesis.

Recently, we identified that the atypical protein kinase C isoform ι (PKCι) enhances the expression of Yes-associated protein 1 (YAP1) to promote the tumorigenesis of pancreatic adenocarcinoma harboring mutant KRAS (mu-KRAS). To advance our understanding about underlying mechanisms, we analyze the transcription of YAP1 in pancreatic cancer cells and reveal that transcription factor specificity protein 1 (Sp1) is upregulated by PKCι and subsequently binds to multiple sites in YAP1 promoter to drive the transactivation of YAP1 in pancreatic cancer cells carrying mu-KRAS. The bioinformatics analysis further substantiates that the expression of PKCι, Sp1 and YAP1 is correlated and associated with the stages and prognosis of pancreatic tumors.

An improved beam splitting method for intensity modulated proton therapy.

The pencil beam algorithm (PBA) has become the predominant dose calculation method in proton therapy, due to its high level of efficiency. However, density heterogeneity decreases the accuracy of PBA. To improve PBA's accuracy, a beam splitting method is used to divide the original scanning beam into multiple thinner beamlets.

[The Effects of PKCι on Anti-tumor Activity of Cytokine-induced Killer Cells Against Pancreatic Cancer Cells and the Possible Underlying Mechanisms].

Objective: To study the impact of atypical protein kinase Cι (PKCι) isoform PKC on the pancreatic cancer cells towards the tumoricidal effect of cytokine-induced killer (CIK) cells and explore its mechanisms.

Methods: CIK cells were prepared by inducing mononuclear cells isolated from the peripheral blood of healthy people with interleukin-2 (IL-2), interferon (IFN) and CD3 mAb and subsequently co-cultured with pancreatic epithelial cell HPDE6-C7, pancreatic cancer cells MiaPaCa and PANC-1 with or without PKC inhibitor named sodium thiomalate (ATM). All cells were divided into control group, ATM group, co-culture group with CIK and co-culture group with CIK+ATM.

Mu-KRAS attenuates Hippo signaling pathway through PKCι to sustain the growth of pancreatic cancer.

The atypical protein kinase C isoform ι (PKCι) is upregulated, which cooperates with mutated KRAS (mu-KRAS) to promote the development of pancreatic cancers. However, the exact role of PKCι in KRAS-mediated pancreatic tumorigenesis is not fully defined. In the present study, we demonstrate that mu-KRAS upregulates and activates PKCι, accompanied by dephosphorylation of large tumor suppressor (LATS), a key member of the growth-inhibiting Hippo signaling pathway.

Study on the interaction between silver nanoparticles and nucleic acids in the presence of cetyltrimethylammonium bromide and its analytical application.

A novel method is proposed in this paper, that is the silver nanoparticle (nanoAg)-cetyltrimethylammonium bromide (CTMAB) is used as the probe of resonance light scattering (RLS) for the determination of nucleic acids. Under optimum conditions, there are linear relationships between the quenching extent of RLS and the concentration of nucleic acids in the range of 4.0x10(-9)-2.