A Comprehensive Review of the Chemical Constituents and Functional Properties of Adzuki Beans ().

The adzuki bean (), a member of the genus within the Leguminosae family, is native to China and extensively cultivated across East Asia. Renowned for its rich nutritional profile, the adzuki bean is abundant in carbohydrates, proteins, and bioactive compounds such as polysaccharides, polyphenols, flavonoids, saponins, and peptides. These components confer a wide range of health-promoting properties, including potent antioxidant, anti-inflammatory, antidiabetic, antiobesity, antibacterial, and neuroprotective effects.

Anti-depression molecular mechanism elucidation of the phytochemicals in edible flower of Baroni.

The edible flower of Baroni, commonly known as "Huang Huacai" in China, has anti-depressant effects. However, targets and molecular mechanisms of Baroni edible flowers (HEF) in depression treatment are still unclear. The potential anti-depression targets in HEF were identified by the intersecting results from typical drug databases.

Anti-Obesity Effects of Adzuki Bean Saponins in Improving Lipid Metabolism Through Reducing Oxidative Stress and Alleviating Mitochondrial Abnormality by Activating the PI3K/Akt/GSK3β/β-Catenin Signaling Pathway.

Obesity is a chronic and complex disease defined by the excessive deposition of fat and is highly associated with oxidative stress. Adzuki bean saponins (ABS) showed anti-obesity activity in our previous in vivo study; however, the active saponins of adzuki beans and potential mechanisms are still unclear. This research aims to elucidate the anti-obesity effects of ABS in improving lipid metabolism and oxidative stress, exploring the effective ingredients and potential molecular mechanisms through UHPLC-QE-MS analysis, network pharmacology, bioinformatics, and in vitro experiments both in the 3T3-L1 cell line and HepG2 cell line.

Elucidation of Anti-Obesity Mechanisms of Phenolics in Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking.

The global prevalence of obesity is a pressing health issue, increasing the medical burden and posing significant health risks to humans. The side effects and complications associated with conventional medication and surgery have spurred the search for anti-obesity drugs from plant resources. Previous studies have suggested that Folium (Aiye) water extracts could inhibit pancreatic lipase activities, control body weight increase, and improve the plasma lipids profile.

Potential anti-obesity effect of saponin metabolites from adzuki beans: A computational approach.

In contrast to its widespread traditional and popular culinary use to reduce weight, (adzuki beans) was not subjected to sufficient scientific scrutiny. Particularly, its saponins whose role was never investigated before to unveil the beans' antidiabetic and anti-obesity effects. Four vital pancreatic and intestinal carbohydrate enzymes were selected to assess the potency of the triterpenoidal saponins of to bind and activate these proteins through high-precision molecular modeling and dynamics mechanisms with accurate molecular mechanics Generalized Born Surface Area (MMGBSA) energy calculations; thus, recognizing their anti-obesity potential.

Revealing Molecular Mechanisms of the Bioactive Saponins from Edible Root of in Combating Obesity.

Obesity has emerged as a significant health concern, as it is a disease linked to metabolic disorders in the body and is characterized by the excessive accumulation of lipids. As a plant-derived food, (PG) was reported by many studies, indicating that the saponins from PG can improve obesity effectively. However, the anti-obesity saponins from PG and its anti-obesity mechanisms have not been fully identified.

Critical review on anti-inflammation effects of saponins and their molecular mechanisms.

This review highlights the increasing interest in one of the natural compounds called saponins, for their potential therapeutic applications in addressing inflammation which is a key factor in various chronic diseases. It delves into the molecular mechanisms responsible for the anti-inflammatory effects of these amphiphilic compounds, prevalent in plant-based foods and marine organisms. Their structures vary with soap-like properties influencing historical uses in traditional medicine and sparking renewed scientific interest.

A critical review on intestinal mucosal barrier protection effects of dietary polysaccharides.

Studies have shown that dietary polysaccharides, which are widely present in natural foods, have an important impact on the intestinal mucosal barrier. Dietary polysaccharides can maintain the intestinal barrier function through multiple mechanisms. The intestinal barrier is composed of mechanical, chemical, immune, and biological barriers, and dietary polysaccharides, as a bioactive component, can promote and regulate these four barriers.

Network pharmacology and bioinformatics to identify the molecular mechanisms of Gleditsiae Spina against colorectal cancer.

Objective: In this study, network pharmacology, bioinformatics and molecular docking were used to explore the active phytochemicals, hub genes, and potential molecular mechanisms of Gleditsiae Spina in treating of colorectal cancer..

Methods: The targets of Gleditsiae Spina, and targets related to CRC were derived from databases.

Network Pharmacology and Bioinformatics Study of Geniposide Regulating Oxidative Stress in Colorectal Cancer.

This study aims to identify the mechanism of geniposide regulating oxidative stress in colorectal cancer (CRC) through network pharmacology and bioinformatics analysis. Targets of geniposide, oxidative stress-related targets and targets related to CRC were applied from databases. The hub genes for geniposide regulating oxidative stress in CRC were identified with the protein-protein interaction (PPI) network.

Insights into the Chemical Compositions and Health Promoting Effects of Wild Edible Mushroom .

is an edible mushroom that has been an important food source since ancient times. It is increasingly sought after for its unique flavor and medicinal value. It is one of the most important wild mushrooms for its medicinal and economic value.

Critical review on anti-obesity effects of phytochemicals through Wnt/β-catenin signaling pathway.

Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by inhibiting the transcription and translation of adipogenesis transcription factors such as C/EBPα and PPARγ.

Bearing Performance Degradation Assessment Based on SC-RMI and Student's t-HMM.

Bearing performance degradation assessment (PDA), as an important part of prognostics and health management (PHM), is significant to prevent major accidents and economic losses in industry. For the data-driven PDA, the extraction and selection of features is quite important. To better integrate the degradation information, the bearing performance degradation assessment based on SC-RMI and Student's t-HMM is proposed in this article.