Tetramethylpyrazine promotes osteo-angiogenesis during bone fracture repair.

Background: Nonunion following a long bone fracture has gained a lot of attention due to the dreadful impact on the life quality of tremendous patients. Recent data have demonstrated the important involvement of angiogenesis in improving fracture healing. Tetramethylpyrazine (TMP) is an active component of Chinese herbal medicine with various biological activities including pro-angiogenesis property.

Tibial cortex transverse distraction in treating diabetic foot ulcers: what are we concerned about?

Objective: To assess the effect and complications of tibial cortex transverse distraction (TCTD) in treating diabetic foot ulcers and draw attention to the concerning issues of this procedure.

Methods: This case series included 30 patients with diabetic foot ulcers from four centers. The ulcers had not healed after >6 months.