Molecular characterization of extended-spectrum β-lactamases from the Akkermansia genus.

Akkermansia muciniphila, a member of the Verrucomicrobiota phylum, is recognized as a key gut microbe and has emerged as a potential next-generation probiotic. Assessment of antibiotic resistance in probiotics is a prerequisite for their application, while very few is studied in Akkermansia species. To address this, eight representative class A β-lactamases (36.

Responses of microbial community to different concentration of perchlorate in the Qingyi River.

Perchlorate is a refractory and mobile contaminant that is wildly distributed in surface water, and due to its tremendous inhibitory effect on mammalian thyroid function, it has gained much attention in recent years. Numerous studies have focused on environmental detection of perchlorate, especially in water. However, less attention has been paid to the effects of perchlorate on the composition of the microbial community in rivers.

Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.

Ochratoxin A (OTA) is a mycotoxin ubiquitous in feeds and foodstuffs. The water-insoluble pentacyclic triterpene bioactive compound, ursolic acid (UA), is widespread in various cuticular waxes of edible fruits, food materials, and medicinal plants. Although studies have reported that oxidative stress was involved in both the nephrotoxicity of OTA and the renoprotective function of UA, the role of stress-responsive Lon protease 1 (Lonp1) in the renoprotection of UA against OTA is still unknown.