Publications by authors named "Jingzhong Duan"
: To improve the solubility and permeability of Sparfloxacin (SPX) and enhance its antimicrobial activity in vitro, two unreported pharmaceutical crystalline salts were synthesized and characterized in this paper. One is a hydrated crystal of Sparfloxacin with Pimelic acid (PIA), another is a hydrated crystal of Sparfloxacin with Azelaic acid (AZA), namely, SPX-PIA-HO (2CHFNO·CHO·2HO) and SPX-AZA-HO (4CHFNO·2CHO·5HO). : The structure and purity of two crystalline salts were analyzed using solid-state characterization methods such as single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and infrared spectroscopy.
View Article and Find Full Text PDFTwo Novel Hydrate Salts of Norfloxacin with Phenolic Acids and Their Physicochemical Properties.
Antibiotics (Basel)
September 2024
Article Synopsis
- Norfloxacin (NORF) is a widely used fluoroquinolone antibiotic that has limitations due to its poor water solubility and low oral bioavailability.
- This study focuses on improving NORF’s biopharmaceutical properties by creating two new hydrate salts using phenolic acid, namely NORF-3,5-DBA hydrate and NORF-VA hydrate.
- The research shows that these salts significantly enhance NORF's solubility and antibacterial effectiveness, demonstrated by better inhibition of bacteria and reduced minimum inhibitory concentration values.