Publications by authors named "Jingzhen Sun"
Engineering the L-tryptophan metabolism for efficient de novo biosynthesis of tryptophol in Saccharomyces cerevisiae.
Biotechnol Biofuels Bioprod
October 2024
Article Synopsis
- - Tryptophol (IET) is a compound derived from L-tryptophan and has various biological activities, yet its industrial production relies on harmful chemical processes rather than renewable sources.
- - This research focuses on engineering the yeast Saccharomyces cerevisiae to produce IET through microbial fermentation, achieving a significant increase in yield (1.04 g/L) compared to the wild-type strain.
- - The study also enhances understanding of aromatic amino acid metabolism in yeast and identifies mutant strains that accumulate valuable precursors, which could be used for producing natural products by introducing additional pathways.