Publications by authors named "Jingzhao Yang"
Targeting the stemness of triple-negative breast cancer (TNBC) is a potential therapeutic approach for treating TNBC. Tetrandrine, a natural plant alkaloid, has several anticancer effects. Here, we aimed to evaluate the efficacy of tetrandrine in cancer stemness and epithelial to mesenchymal transition (EMT) in TNBC, and to explore the underlying mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- Artesunate, a drug approved for severe malaria, has shown potential for treating acute myeloid leukaemia (AML) by inducing apoptosis (cell death) and differentiation in cancer cells.
- Research demonstrated that artesunate works in both lab studies and animal models by increasing reactive oxygen species (ROS) and the protein Bim, along with affecting iron regulation in AML cells.
- The study concluded that artesunate is a safe option with significant anti-leukaemia effects in mice and could potentially be an effective treatment for AML patients, targeting dual pathways.
The molecular mechanisms underlying neuropathic pain (NP) remain poorly understood. Emerging evidence has suggested the role of microRNAs (miRNAs) in the initiation and development of NP, but the specific effects of miRNAs in NP are largely unknown. Here, we use network- and pathway-based methods to investigate NP-induced miRNA changes and their biological functions by conducting a systematic search through multiple electronic databases.
View Article and Find Full Text PDF