Proteomic profiling reveals the significance of lipid metabolism in small cell lung cancer recurrence and metastasis.

Background: Small cell lung cancer (SCLC) is a lethal and recalcitrant malignancy with early metastases. However, the molecular and cellular mechanisms underlying its aggressive characteristics remain relatively elusive.

Methods: In this study, we conducted a comprehensive proteomic analysis of 90 primary tumors, 15 patient-matched lymph node metastatic tumors, and 15 brain metastatic tumors derived from a cohort of 105 SCLC patients.

Deciphering the Interfacial Li-Ion Migration Kinetics of Ni-Rich Cathodes in Sulfide-Based All-Solid-State Batteries.

Nickel-rich layered oxide with high reversible capacity and high working potentials is a prevailing cathode for high-energy-density all-solid-state lithium batteries (ASSLBs). However, compared to the liquid battery system, ASSLBs suffer from poor Li-ion migration kinetics, severe side reactions, and undesired formation of space charge layers, which result in restricted capacity release and limited rate capability. In this work, we reveal that the capacity loss lies in the H2-H3 phase transition period, and we propose that the inconsistent interfacial Li-ion migration is the arch-criminal.

The Immunomodulatory Effects of Lipoteichoic Acid from L1 on RAW264.7 Cells and Mice Vary with Dose.

The probiotic properties of () and its impact on immune function are well-documented. Lipoteichoic acid (LTA) is a crucial immune molecule in Gram-positive bacteria. Despite extensive research on LTA's structural diversity, the immunomodulatory mechanisms of LTA remain largely unexplored.

Deciphering the potential of potassium-ion batteries beyond room temperature.

Alloying-type anode materials are considered promising candidates for next-generation alkali-ion batteries. However, they face significant challenges owing to severe volume variations and sluggish kinetics, which hinder their practical applications. To address these issues, we propose a universal synthetic strategy, which can realize the facile synthesis of various alloying-type anode materials composed of a porous carbon matrix with uniformly embedded nanoparticles (Sb, Bi, or Sn).

Accelerating the electron-transfer of nitrogen electro-fixation through assembling Fe nanoparticles into Fe nanochains.

Electrochemically synthesizing NH N is a facile and sustainable approach that involves multistep electron and proton transfer processes. Thus, consecutive electron and proton transfer is necessary. Here, a universal method with the assistance of magnetic stirring that can assemble Fe, Co, and Ni nanoparticles into nanochains is developed.

PiR-hsa-23533 promotes malignancy in head and neck squamous cell carcinoma via USP7.

Background: With regard to head and neck squamous cell carcinoma (HNSCC), its occurrence and advancement are controlled by genetic and epigenetic anomalies. PIWI-interacting RNAs (piRNAs) are recognized with significance in tumor, but the precise molecular mechanisms of piRNAs in HNSCC largely remain undisclosed.

Methods: Differentially expressed piRNAs were identified by RNA sequencing.

Microstructures of layered Ni-rich cathodes for lithium-ion batteries.

Millions of electric vehicles (EVs) on the road are powered by lithium-ion batteries (LIBs) based on nickel-rich layered oxide (NRLO) cathodes, and they suffer from a limited driving range and safety concerns. Increasing the Ni content is a key way to boost the energy densities of LIBs and alleviate the EV range anxiety, which are, however, compromised by the rapid performance fading. One unique challenge lies in the worsening of the microstructural stability with a rising Ni-content in the cathode.

Interface Engineering Enables Wide-Temperature Li-Ion Storage in Commercial Silicon-Based Anodes.

Silicon-based materials have been considered potential anode materials for next-generation lithium-ion batteries based on their high theoretical capacity and low working voltage. However, side reactions at the Si/electrolyte interface bring annoying issues like low Coulombic efficiency, sluggish ionic transport, and inferior temperature compatibility. In this work, the surface Al O coating layer is proposed as an artificial solid electrolyte interphase (SEI), which can serve as a physical barrier against the invasion of byproducts like HF(Hydrogen Fluoride) from the decomposition of electrolyte, and acts as a fast Li-ion transport pathway.

Building Stable Anodes for High-Rate Na-Metal Batteries.

Due to low cost and high energy density, sodium metal batteries (SMBs) have attracted growing interest, with great potential to power future electric vehicles (EVs) and mobile electronics, which require rapid charge/discharge capability. However, the development of high-rate SMBs has been impeded by the sluggish Na ion kinetics, particularly at the sodium metal anode (SMA). The high-rate operation severely threatens the SMA stability, due to the unstable solid-electrolyte interface (SEI), the Na dendrite growth, and large volume changes during Na plating-stripping cycles, leading to rapid electrochemical performance degradations.

Dietary Nucleotides Promote Neonatal Rat Microbiota-Gut-Brain Axis Development by Affecting Gut Microbiota Composition and Metabolic Function.

A variety of active factors in milk and foods have been proven to serve as microbial nutrients that regulate the formation of early gut microbiota (GM), thereby ensuring the healthy development of infants. This study demonstrated that dietary nucleotides (NTs), one of the main nitrogen-containing substances in human milk, promoted the neurodevelopment of neonatal rats and the expression of Sox2, Dcx, Tuj1, and NeuN in the prefrontal cortex and hippocampus, but had no significant regulatory effects in the striatum. 16s rRNA sequencing and metabolomics of the colon contents of neonatal rats at different developmental stages showed that the early intake of NTs promoted an increase in the abundance of beneficial microorganisms related to neurodevelopment, digestion, and gut absorption, such as and Changes in the ability of the GM to regulate folate synthesis, riboflavin metabolism, and other processes were also observed.

Combined signature of N7-methylguanosine regulators with their related genes and the tumor microenvironment: a prognostic and therapeutic biomarker for breast cancer.

Background: Identifying predictive markers for breast cancer (BC) prognosis and immunotherapeutic responses remains challenging. Recent findings indicate that N-methylguanosine (m7G) modification and the tumor microenvironment (TME) are critical for BC tumorigenesis and metastasis, suggesting that integrating m7G modifications and TME cell characteristics could improve the predictive accuracy for prognosis and immunotherapeutic responses.

Methods: We utilized bulk RNA-sequencing data from The Cancer Genome Atlas Breast Cancer Cohort and the GSE42568 and GSE146558 datasets to identify BC-specific m7G-modification regulators and associated genes.

A nomogram for predicting mild cognitive impairment in older adults with hypertension.

Background: Hyper- and hypotension increase the risk of cognitive dysfunction. As effective control of blood pressure can reduce the risk of mild cognitive impairment (MCI), early risk assessment is necessary to identify MCI in senile hypertension as soon as possible and reduce the risk of developing dementia. No perfect risk-prediction model or nomogram has been developed to evaluate the risk of MCI in older adults with hypertension.

The efficacy and safety of telerehabilitation for patients following total knee arthroplasty: a overviews of systematic reviews.

Background: Studies evaluating the effectiveness and safety of telerehabilitation in patients undergoing total knee arthroplasty (TKA) have increased. However, the study quality and results differ, systematic reviews are limited. We aimed to synthesise systematic reviews and meta-analyses to assess the effects of telerehabilitation in patients post-TKA.

Clinical study on single-port endoscopic resection via a gasless transaxillary approach in the treatment of breast fibroadenoma in adolescents.

Background: Breast fibroadenoma is the most common benign breast tumour. This study aimed to investigate the advantages and disadvantages of endoscopic-assisted resection via a gas-less transaxillary single-port approach for breast fibroadenoma in adolescent patients, compared with a traditional approach.

Methods: The clinical data of 83 patients with breast fibroadenoma treated in our hospital from October 2019 to October 2021 were collected for retrospective analysis.

A Deep Learning Method for Rolling Bearing Fault Diagnosis Based on Attention Mechanism and Graham Angle Field.

Focusing on the low accuracy and timeliness of traditional fault diagnosis methods for rolling bearings which combine massive amounts of data, a fault diagnosis method for rolling bearings based on Gramian angular field (GAF) coding technology and an improved ResNet50 model is proposed. Using the Graham angle field technology to recode the one-dimensional vibration signal into a two-dimensional feature image, using the two-dimensional feature image as the input for the model, combined with the advantages of the ResNet algorithm in image feature extraction and classification recognition, we realized automatic feature extraction and fault diagnosis, and, finally, achieved the classification of different fault types. In order to verify the effectiveness of the method, the rolling bearing data of Casey Reserve University are selected for verification, and compared with other commonly used intelligent algorithms, the results show that the proposed method has a higher classification accuracy and better timeliness than other intelligent algorithms.

The E3 ubiquitin ligase MIB1 suppresses breast cancer cell migration through regulating CTNND1 protein level.

Breast cancer is one of the most common invasive cancers among women. The leading cause of difficulty in treating breast cancer patients is metastasis. Because cell migration is closely related to breast cancer metastasis, elucidating the detailed mechanism by which breast cancer cells promote their migration is crucial for improving the prognosis of patients.

Differential reinforcement of intestinal barrier function by various Lactobacillus reuteri strains in mice with DSS-induced acute colitis.

Aims: Inflammatory bowel disease is a complex, refractory disorder characterised by chronic gastrointestinal inflammation. Studies have reported that Lactobacillus reuteri alleviates gastrointestinal inflammation and strengthens the intestinal barrier. However, further biochemical and genetic studies are required to correctly understand the therapeutic potential of L.

Ultrathin metal-organic framework nanosheets as building blocks of lamellar nanofilms for ultrafast molecular sieving.

Metal-organic framework (MOF) nanosheets have significant potential applications including separation, catalysis, and sensors. However, the on-demand design with tunable thickness and morphology remains a great challenge, leading to difficulties in modulating their hierarchical assembly for the preparation of macroscopic films. Herein, we report the successful synthesis of smooth and ultrathin MOF (Cu-TCPP (TCPP = 4,4,4,4-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid))) nanosheets used in lamellar nanofilms for the rejection of organic molecules from water.

Topological polarization singular lasing with highly efficient radiation channel.

Bound states in the continuum (BICs) in photonic crystals describe the originally leaky Bloch modes that can become bounded when their radiation fields carry topological polarization singularities. However, topological polarization singularities do not carry energy to far field, which limits radiation efficiencies of BICs for light emitting applications. Here, we demonstrate a topological polarization singular laser which has a topological polarization singular channel in the second Brillouin zone and a paired linearly polarized radiation channel in the first Brillouin zone.

Physiological and molecular mechanisms of the response of roots of Lamb. to low-temperature stress.

Lamb. is the timber species with the widest distribution and the largest afforestation area in China, providing a large amount of timber, turpentine and ecological products. but low temperature limits its growth and geographical distribution.

Identification of WRKY transcription factor family genes in Pinus massoniana Lamb. and their expression patterns and functions in response to drought stress.

Background: Pinus massoniana Lamb. is the timber species with the widest distribution and the largest afforestation area in China, providing a large amount of timber, turpentine and ecological products. Seasonal drought caused by climate warming severely constrains the quality and growth of P.

Is Effective in Relieving Type 2 Diabetes and May Be Related to Its Dominant Core Genome and Gut Microbiota Modulation Capacity.

The prevalence of diabetes mellitus is increasing globally. Probiotics have been shown to be an effective intervention for diabetes. This study focused on the relieving effects and possible mechanisms of 16 strains of two dominant species ( and , which exist in the human gut at different life stages) on type 2 diabetes (T2D).