A mitochondria-targeted fluorescent probe based on an anti-diffusion strategy for in situ imaging of fatty liver, inflammation and cancer.

Abnormal mitochondrial viscosity is closely associated with a wide range of diseases and cellular dysfunction. It is crucial to develop fluorescent probes for precisely monitoring changes of mitochondrial viscosity in the detection and treatment of associated diseases. However, mitochondria-targeted fluorescent probes currently faced off-target problems because their high water-solubility could hinder the accurate detection of mitochondrial viscosity.

High Molecular Weight Polyacrylonitrile Precursor for S@pPAN Composite Cathode Materials with High Specific Capacity for Rechargeable Lithium Batteries.

Sulfurized pyrolyzed poly(acrylonitrile) (S@pPAN) demonstrates high sulfur utilization, no polysulfide dissolution, no self-discharge, and extremely stable cycling. Its precursor, PAN, directly determines the performances of cathode materials, including the sulfur content and its utilization for S@pPAN composite materials. Adopting PAN with the molecular weight approaching 550,000 as the precursor, the sulfur content in S@pPAN approaches 55 wt %, and its reversible specific capacity was 901 mAh g at 50 °C with sulfur utilization over 98%.

Highly Reversible Lithium-Metal Anode and Lithium-Sulfur Batteries Enabled by an Intrinsic Safe Electrolyte.

Rechargeable lithium-metal batteries have gained significant attention as potential candidates of energy storage systems; however, severe safety issues including flammable electrolyte and dendritic lithium formation hinder their further practical application. In this work, we develop a novel intrinsic flame-retardant electrolyte, which enables a stable and dendrite-free cycling with lithium plating/stripping Coulombic efficiency of up to 99.1% over 500 cycles.

Reversal effects of Raloxifene on paclitaxel resistance in 2 MDR breast cancer cells.

Raloxifene hydrochloride (RAL), one of second generation of selective estrogen receptor modulators (SERMs), is usually used in preventing osteoporosis and breast cancer. The present study evaluated whether Raloxifene might sensitize multidrug resistant (MDR) breast cancers to chemotherapies, especially in estrogen receptor negative (ER-) breast cancer. The results showed that RAL could significantly sensitize ER- MDR breast tumors to paclitaxel both in vitro and in vivo.

[Research relating the use of systematic drug and cataracts].

Cataract is the leading cause of blindness in the world. The use of certain drugs is one of the risk factors for lens opacities, such as glucocorticoids and chlorpromazine. We reviewed new studies regarding the relationship between cataract formation and drugs that have become more widely used in recent years, such as statins, anti-epileptic drugs, antidepressants, tamoxifen, amiodarone, eltrombopag, isotretinoin, nifedipine and quetiapine.