Publications by authors named "Jingyin Liang"
Article Synopsis
- ACAA2 is an important enzyme in fatty acid metabolism and is linked to tumor development and progression, especially in ovarian cancer, though its exact role was previously unclear.
- Research analyzed ACAA2's expression, conducted functional experiments, and utilized RNA-seq to uncover its regulatory mechanisms in ovarian cancer.
- Findings suggest that ACAA2 promotes cancer cell growth and spread, possibly through the WNT/β-Catenin pathway, indicating it may serve as an oncogene and a potential therapeutic target in ovarian cancer treatment.
Article Synopsis
- PGK1 is an enzyme implicated in various diseases, including non-small cell lung cancer (NSCLC), where its dysregulation is linked to poor prognosis and increased tumor growth.
- The study explored PGK1's role in NSCLC using bioinformatics, lab experiments, and mouse models, revealing its influence on cancer cell proliferation and metastasis through O-GlcNAcylation.
- The findings highlight the miR-24-3p/OGT axis driving PGK1's effects, making it a potential target for NSCLC therapy.
The O-glycosylating enzyme GALNT2 acts as an oncogenic driver in non-small cell lung cancer.
Cell Mol Biol Lett
September 2022
Background: N-Acetylgalactosaminyltransferases (GALNTs), the enzymes that initiate mucin-type O-glycosylation, are closely associated with tumor occurrence and progression. However, a comprehensive analysis of GALNTs in non-small cell lung cancer (NSCLC) is lacking.
Methods: The expression profiles and prognostic values of the GALNT family members in NSCLC were analyzed using publicly available databases.