Intestinal fungi, collectively referred to as mycobiota, constitute a small (0.01-2%) but crucial component of the overall intestinal microbiota. While fungi are far less abundant than bacteria in the gut, the volume of an average fungal cell is roughly 100-fold greater than that of an average bacterial cell.
View Article and Find Full Text PDFRationale And Objectives: Accurate identification of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is crucial for treatment and prognosis. Single-modality and feature fusion models using manual segmentation fail to provide insights into MVI. This study aims to develop a DeepLab V3+ model for automated segmentation of HCC magnetic resonance (MR) images and a decision fusion model to predict MVI and early recurrence (ER).
View Article and Find Full Text PDFIntroduction: In order to elucidate the physiological mechanism of post-flowering assimilate transport regulating the formation of yields in arid regions and to provide technological support for further water-saving and high yields in the wheat region in Xinjiang, we conducted a study on the effects of different fertility periods and different degrees of drought and re-watering on the post-flowering dry matter accumulation and transport of spring wheat and the characteristics of grain filling.
Methods: In two spring wheat growing seasons in 2023 and 2024, a split-zone design was used, with the drought-sensitive variety Xinchun 22 (XC22) and drought-tolerant variety Xinchun 6 (XC6) as the main zones and a fully irrigated control during the reproductive period [CK, 75%~80% field capacity (FC)], with mild drought at the tillering stage (T1, 60%~65% FC), moderate drought at the tillering stage (T2, 45%~50% FC), mild drought at the jointing stage (J1, 60%~65% FC), and mild drought at the jointing stage (J2, 45%~50% FC) as the sub-zones.
Results: The dry matter accumulation of the aboveground parts of wheat (stem sheaths, leaves, and spikes), the transfer rate and contribution rate of nutrient organs, the maximum filling rate (V), and the mean filling rate (V) increased significantly after re-watering in the T1 treatment, and decreased with the deepening of the degree of water stress.
Tissue-resident fibroblasts with immunomodulatory properties have recently been identified as key players in inflammation. However, their roles within the periodontal niche in diabetes-associated periodontitis remain unclear. Interleukin (IL)-33, known as an "alarmin" in inflammatory responses, has recently emerged as a potential contributor to periodontitis.
View Article and Find Full Text PDFBackground: Pruritus ani (PA), a neurofunctional dermatosis, is one of the most common complications of hemorrhoids, which seriously affects the quality of life of patients. Medical hemorrhoid gel (MHG), a product mainly composed of herbal medicine, is widely used for treatment of PA clinically. This study aim to assess the alleviating effect and mechanism of MHG on PA based on rectal epidermis-spinal cord-brain axis using animal models.
View Article and Find Full Text PDFPurpose: Threonine (Thr) can be involved in the synthesis of immunoglobulins, which play the role of immune regulation, Thr also has to improve intestinal morphology, adjust the sticky protein synthesis, maintain the intestinal barrier function, etc. The experiment aimed to investigate the effects of diets supplemented with different levels of Thr on growth performance and intestinal health of rabbits under lipopolysaccharide (LPS) stress conditions.
Methods: A total of 180 healthy 35-day-old weaned New Zealand White rabbits were randomly assigned in a 2 × 3 factorial design to receive an intraperitoneal injection of 100 µg/kg BW LPS or saline and three diets with different levels of digestible threonine (0.
Too identify seleniut(Se) content characteristics and influencing factors in soil and crops of Shengli Farm in eastern Sanjiang Plain, statistical analysis and correlation analysis were comprehensively used to analyze the test results of 83 groups of surface soil samples and 34 groups of crop seed samples. The results showed that the Se content in the study area ranged from 0.12 to 0.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
The massive yield of brewers' spent grain (BSG) waste inevitably threaten environmental health. Here, solid-state fermentation (SSF) technology featuring multi-strain (MS) inoculation and high-throughput sequencing technology were employed to facilitate the sustainable and clean recycling of BSG waste while revealing the associated underlying microbiological and metabolic mechanisms. MS inoculation displayed a lower pH value (3.
View Article and Find Full Text PDFJ Nurs Scholarsh
September 2024
Introduction: Given that stroke is a leading cause of disability and mortality worldwide, there is an urgent need for a coordinated healthcare approach to mitigate its effects. The objectives of this study were to perform a systematic review and meta-analysis of stroke integrated care models and develop recommendations for a representative model.
Design: A systematic review and meta-analysis.
Diarrheas are common risks faced by piglets during the weaning period. This study investigated the alleviating effects of artificial parasin I protein (API) on growth performance and intestinal health of weaned pigs upon enterotoxigenic (ETEC) challenge. Sixty piglets were randomly divided into five groups and fed a basal diet (CON) or basal diet supplemented with API at 0, 750, and 1500 mg/kg or antibiotics for 5 weeks.
View Article and Find Full Text PDFThe objectives of this study were to investigate the effects of extrusion on the chemical compositions, surface structure, and molecular structure of brewer's spent grain (BSG), as well as to determine the digestible energy (DE), metabolizable energy (ME), apparent total tract digestibility (ATTD) of nutrients and energy, and amino acid (AA) digestibility of extruded BSG when fed to growing pigs. Firstly, we determined the changes in chemical compositions and molecular structure of both non-extruded and extruded BSG. In Exp.
View Article and Find Full Text PDFBone and cartilage tissues are physiologically dynamic organs that are systematically regulated by mechanical inputs. At cellular level, mechanical stimulation engages an intricate network where mechano-sensors and transmitters cooperate to manipulate downstream signaling. Despite accumulating evidence, there is a notable underutilization of available information, due to limited integration and analysis.
View Article and Find Full Text PDFLiving cells navigate a complex landscape of mechanical cues that influence their behavior and fate, originating from both internal and external sources. At the molecular level, the translation of these physical stimuli into cellular responses relies on the intricate coordination of mechanosensors and transducers, ultimately impacting chromatin compaction and gene expression. Notably, epigenetic modifications on histone tails govern the accessibility of gene-regulatory sites, thereby regulating gene expression.
View Article and Find Full Text PDFBackground: At present, heat stress (HS) has become a key factor that impairs broiler breeding industry, which causes growth restriction and poor meat quality of broilers. Selenium (Se) is an excellent antioxidant and plays a unique role in meat quality improvement. Recent years, nano-selenium (NanoSe) has received tremendous attention in livestock production, due to its characteristic and good antibacterial performance in vitro.
View Article and Find Full Text PDFThe safety of Jatropha curcas L. cake (JCC) in animal feed remains under scrutiny, despite the advent of low phorbol ester (PE) variants. This study investigates the impact of low PE JCC on swine health when used as a protein feed.
View Article and Find Full Text PDFThe use of next-generation probiotics (NGP) in pigs for combating diseases has been subject to limited research. Here we explored the potential of a well-known NGP candidate targeting pig gut health. In the first screening experiment, we found that the abundance of peaked at 14 d old but decreased at weaning (21 d old; < 0.
View Article and Find Full Text PDFEpilepsy is a chronic neurological disorder characterized by episodic dysfunction of central nervous system. The most basic mechanism of epilepsy falls to the imbalance between excitation and inhibition. In adults, GABA receptor (GABAR) is the main inhibitory receptor to prevent neurons from developing hyperexcitability, while its inhibition relies on the low intracellular chloride anion concentration ([Cl]).
View Article and Find Full Text PDFJ Anim Physiol Anim Nutr (Berl)
September 2024
Given the escalating global crisis in feed protein availability, Jatropha curcas L. cake has attracted significant interest as a viable alternative protein source in animal feed. This experiment was conducted to investigate the effects of fermented Jatropha curcas L.
View Article and Find Full Text PDFThis work aimed to propose a rapid method to screen the bioactive peptides with anti-α-glucosidase activity instead of traditional multiple laborious purification and identification procedures. 242 peptides binding to α-glycosidase were quickly screened and identified by bio-affinity ultrafiltration combined with LC-MS/MS from the double enzymatic hydrolysate of black beans. Top three peptides with notable anti-α-glucosidase activity, NNNPFKF, RADLPGVK and FLKEAFGV were further rapidly screened and ranked by the three artificial intelligence tools (three-AI-tool) BIOPEP database, PeptideRanker and molecular docking from the 242 peptides.
View Article and Find Full Text PDFObjective: College students are currently grappling with severe mental health challenges, and research on artificial intelligence (AI) related to college students mental health, as a crucial catalyst for promoting psychological well-being, is rapidly advancing. Employing bibliometric methods, this study aim to analyze and discuss the research on AI in college student mental health.
Methods: Publications pertaining to AI and college student mental health were retrieved from the Web of Science core database.
This study investigated the effect of Ethylenediamine dihydroiodide (EDDI) on growth performance, immune function and intestinal health of meat ducks challenged with Avian pathogenic Escherichia coli (APEC). A total of 360 one-day-old Cherry Valley ducks with similar body weight were randomly allocated to 6 treatments (6 floor cages, 10 birds/cage). A 3 × 2 factor design was used with 3 dietary iodine levels (0, 8, 16 mg/kg in the form EDDI and whether APEC was challenged or not at 7-day-old ducks.
View Article and Find Full Text PDFBackground: The aim of this experiment was to investigate the effect of different levels of betaine (Bet) inclusion in the diet on the intestinal health of growing rabbits under summer heat. A total of 100 weaned Qixing meat rabbits aged 35 d with body weight of 748.61 ± 38.
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