Publications by authors named "Jingye Pan"

Background: Sepsis is a systemic inflammatory response syndrome triggered by infection, often accompanied by severe coagulopathy, leading to high mortality. Tissue factor (TF) plays a pivotal role in sepsis by promoting both coagulation and inflammation. Recently, TREM2 (Triggering Receptor Expressed on Myeloid cells 2) has emerged as a key regulator of macrophage function, but its specific role in sepsis remains unclear.

View Article and Find Full Text PDF

Traditional Chinese medicine (TCM) has played a positive role in preventing and controlling the coronavirus disease 2019 (COVID-19) epidemic. Qingjie formula (QJF) developed to prevent COVID-19 is widely used in Wenzhou, Zhejiang province, China. However, the biological active ingredients of QJF and their specific mechanisms for preventing COVID-19 remain unclear.

View Article and Find Full Text PDF
Article Synopsis
  • The study examines the relationship between the Triglyceride-glucose (TyG) index and overall mortality in critically ill patients with alcohol use disorder (AUD).
  • The research used patient data from the MIMIC-IV database and found that higher TyG values correlated with increased risk of both 28-day and 1-year mortality in these patients.
  • The findings suggest that the TyG index could be an important indicator for predicting clinical outcomes in critically ill individuals suffering from AUD.
View Article and Find Full Text PDF

Cirrhosis represents a significant global health challenge, characterized by high morbidity and mortality rates that severely impact human health. Timely and precise prognostic assessments of liver cirrhosis are crucial for improving patient outcomes and reducing mortality rates as they enable physicians to identify high-risk patients and implement early interventions. This paper features a thorough literature review on the prognostic assessment of liver cirrhosis, aiming to summarize and delineate the present status and constraints associated with the application of traditional prognostic tools in clinical settings.

View Article and Find Full Text PDF
Article Synopsis
  • * Using data from 948 SIC patients admitted to an ICU, researchers evaluated liver fibrosis through three specific scoring systems and found that higher scores correlated with increased mortality rates.
  • * Results indicated that patients with the highest liver fibrosis scores (Fib-4 and NFS) had significantly greater odds of dying in the hospital, highlighting the importance of assessing liver health in these critical cases.
View Article and Find Full Text PDF

Background: Acute lung injury (ALI)-induced acute respiratory syndromes is a critical pathological sequala of sepsis. Araloside A (ARA), extracted from Aralia taibaiensis, possesses anti-oxidative and pro-apoptotic effects, as well as a protective effect against inflammatory diseases such as gastric ulcers. However, its impact on progression of ALI remains unknown.

View Article and Find Full Text PDF
Article Synopsis
  • A fetus in China with an intronic variant in the COL4A2 gene was diagnosed prenatally with severe brain damage, including cerebral encephalomalacia and subdural hemorrhage.
  • Whole exome sequencing identified a specific genetic variant (c.549 + 5G > A) that causes the COL4A2 protein to be shortened, due to skipping of an important exon.
  • This research highlights the pathogenic nature of the variant and enhances the understanding of genetic contributions to fetal neurological disorders, which can aid in future genetic testing and counseling efforts.
View Article and Find Full Text PDF

Background And Aims: Acetaminophen (APAP) is the main cause of acute liver injury (ALI) in the Western. Our previous study has shown that fenofibrate activated hepatic expression of fibroblast growth factor 21 (FGF21) can protect the liver form APAP injuries by promoting autophagy. However, the underlying mechanism involved in FGF21-mediated autophagy remains unsolved.

View Article and Find Full Text PDF

Background And Aim: To date, the association between glucocorticoid use and the risk of pancreatitis remains controversial. The aim of this study was the investigation of this possible relationship.

Methods: We carried out a two-sample Mendelian randomization (MR) analysis using GWAS data from European ancestry, East Asian descendants and the FinnGen Biobank Consortium to evaluate this potential causal relationship.

View Article and Find Full Text PDF

Edema of the prepuce is a common clinical complication following circumcision in urology. Nevertheless, the principal method of gauze wrapping in clinical practice has not yet been demonstrated to be an effective solution to the problem of postoperative edema. It is therefore evident that the development of functional dressings for the treatment of post-circumcision edema has considerable potential for both clinical application and translational significance.

View Article and Find Full Text PDF

Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, whose etiology is intimately related to the overproduction of hypochlorous acid (HClO). Optical monitoring of HClO in the living body favors real-time diagnosis of inflammatory diseases. However, HClO-activated near-infrared (NIR) fluorescent probes with rapid response and high inflammatory cell uptake are still lacking.

View Article and Find Full Text PDF

Background & Aims: Sepsis, a globally prevalent and highly lethal condition, remains a critical medical challenge. This investigation aims to assess the relevance of FGF1 as a potential therapeutic target for sepsis.

Methods: Sepsis was induced in C57BL/6 mice through LPS administration to establish an in vivo animal model.

View Article and Find Full Text PDF
Article Synopsis
  • Factor XI (FXI) deficiency is a genetic bleeding disorder primarily affecting Ashkenazi Jews and some European populations, but it's less understood in East Asians.
  • In a study of 41 FXI-deficient patients, most had severe deficiencies, with only a few experiencing mild bleeding, and significant genetic defects were found in 90% of cases.
  • The research identified 17 variants in the F11 gene, including six novel ones, highlighting that certain variants were prevalent in East Asia and Southeast China, which could help in understanding the disorder in these populations.
View Article and Find Full Text PDF

Sepsis, a life-threatening medical condition, manifests as new or worsening organ failures due to a dysregulated host response to infection. Many patients with sepsis have manifested a hyperinflammatory phenotype leading to the identification of inflammatory modulation by corticosteroids as a key treatment modality. However, the optimal use of corticosteroids in sepsis treatment remains a contentious subject, necessitating a deeper understanding of their physiological and pharmacological effects.

View Article and Find Full Text PDF

Background: Severe inflammation and oxidative stress are characteristics of sepsis-associated kidney injury with high morbidity and mortality. Eriocitrin (ERI) has shown promise in suppressing sepsis-associated kidney injury and LPS-induced periodontal disease, however, its efficacy in alleviating SAKI remains unexplored. This study aimed to investigate the therapeutic potential of ERI on SAKI through in vivo and in vitro experiments, elucidating its underlying mechanism.

View Article and Find Full Text PDF

Background: Acute pancreatitis (AP) is a potentially lethal acute disease highly involved in coagulation disorders. Pyroptosis has been reported to exacerbate coagulation disorders, yet this implication has not been illustrated completely in AP.

Methods: RNA sequencing data of peripheral blood of AP patients were downloaded from the Gene Expression Omnibus database.

View Article and Find Full Text PDF

This study aimed to investigate the prognostic value of a novel droplet digital polymerase chain reaction (DDPCR) assay in sepsis patients. In this prospective cohort study, univariable and multivariable Cox regressions were used to assess risk factors for 28-day mortality. We also monitored pathogen load together with clinical indicators in a subgroup of the cohort.

View Article and Find Full Text PDF

Uncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims to develop a hemostatic product for hemorrhage management. In this study, waste pomelo peel as raw material is chosen.

View Article and Find Full Text PDF

Objective: To achieve a better prediction of in-hospital mortality, the Sequential Organ Failure Assessment (SOFA) score needs to be adjusted and combined with comorbidities. This study aims to enhance the prediction of SOFA score for in-hospital mortality in patients with Sepsis-3. Methods: This study adjusted the maximum SOFA score within the first 3 days (Max Day3 SOFA) in relation to in-hospital mortality using logistic regression and incorporated the age-adjusted Charlson Comorbidity Index (aCCI) as a continuous variable to build the age-adjusted Charlson Comorbidity Index-Sequential Organ Failure Assessment (aCCI-SOFA) model.

View Article and Find Full Text PDF

Background: The relationship between fibrosis-4 (FIB-4) index and all-cause mortality in critically ill patients with alcohol use disorder (AUD) is unclear. The present study aimed to investigate the predictive ability of FIB-4 for all-cause mortality in critically ill AUD patients and the association between them.

Methods: A total of 2528 AUD patients were included using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionf7qt8dktqaktvi5bqacn4gvo15mi17rm): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once