Gentiopicroside: An updated review of its pharmacological activities and mechanisms.

Gentiopicroside (GPS) is a bioactive iridoid glycoside isolated from Gentianaceae plants. In recent years, GPS has received increasing attention due to its multiple pharmacological activities. This review encapsulates the botanical origin, pharmacological activity, toxicity, and underlying mechanisms of GPS in the treatment of various diseases.

Case series and clinical analysis of acute hydrogen sulfide poisoning: Experience from 10 cases at a hospital in Zhoushan.

This study investigated the etiology, clinical features, and management of acute hydrogen sulfide (HS) poisoning in Zhoushan. A retrospective analysis was conducted on 10 patients admitted to our hospital between August and September 2023 due to two incidents of acute HS poisoning. The first incident involved fishermen working in a fishing cabin (6 patients), while the second involved sanitation workers during sewer maintenance (4 patients).

Neutral Interface Directed 3D Confined Self-Assembly of Block Copolymer: Anisotropic Patterned Particles with Ordered Structures.

Three-dimensional confined self-assembly (3D-CSA) of block copolymers (BCPs) is a distinctive and robust strategy that can yield colloidal polymer particles boasting ordered internal structures and diverse morphologies. The unique advantage of neutral interface lies in its ability to create anisotropic particles with surface patterns. The resulting unique polymer particles exhibit deformability under swelling, coupled with excellent spreadability and optical properties.

Scientometric investigations on dual carbon research: Revealing advancements, key areas, and future outlook.

The dual carbon goal is a systematic project involving the entire society and has a leading and systematic role in the green and low-carbon development of China. In this study, we used the CiteSpace software to visualize and analyze 5809 documents from the core database of Web of Science from 1995 to 2023, covering four aspects: descriptive statistics, network collaboration, research hotspots, and thematic evolution analysis. The number of studies in the field of dual carbon is in an explosive growth stage and China and the Chinese Academy of Sciences have become the core country and institution for research, respectively, in this field.

Recent Progress in Janus Nano-Objects with Asymmetric Polymer Brushes.

Over the past few decades, Janus materials have drawn much interest owing to the combination of two different functionalities on the opposite sides. Janus nano-objects (JNOs) with asymmetric polymer brushes are one unique material of them, which consist of a polymeric or inorganic core and asymmetric polymer chains coated on the core. Combining the properties of nanomaterials, asymmetric structures and flexible polymer brushes, hairy JNOs have shown great potential in interfacial compatibilization, interfacial catalysis, oil-water separation and drug delivery.

The interplay between herbal medicines and gut microbiota in metabolic diseases.

Globally, metabolic diseases are becoming a major public health problem. Herbal medicines are medicinal materials or preparations derived from plants and are widely used in the treatment of metabolic diseases due to their good curative effects and minimal side effects. Recent studies have shown that gut microbiota plays an important role in the herbal treatment of metabolic diseases.

A Versatile 3D-Confined Self-Assembly Strategy for Anisotropic and Ordered Mesoporous Carbon Microparticles.

Mesoporous carbon microparticles (MCMPs) with anisotropic shapes and ordered structures are attractive materials that remain challenging to access. In this study, a facile yet versatile route is developed to prepare anisotropic MCMPs by combining neutral interface-guided 3D confined self-assembly (3D-CSA) of block copolymer (BCP) with a self-templated direct carbonization strategy. This route enables pre-engineering BCP into microparticles with oblate shape and hexagonal packing cylindrical mesostructures, followed by selective crosslinking and decorating of their continuous phase with functional species (such as platinum nanoparticles, Pt NPs) via in situ growth.

Structure Regulation of Block Copolymer Assemblies in Emulsion Droplets by Adding a Selective Solvent.

Generally, nanostructured polymer particles are prepared by 3D confined self-assembly (3D-CSA) of block copolymers (BCPs), while micelles are obtained through self-assembly of BCPs in dilute solutions. Herein, a facile yet robust strategy is developed to regulate the assembled structures of BCP, poly(styrene-block-4-vinylpyridine) (PS-b-P4VP), from nanostructured particles to micelles. The assemblies are prepared by an emulsion-solvent diffusion-induced self-assembly route, which is conducted by dialysis.

Recurrent Talaromyces marneffei Infection Presenting with Intestinal Obstruction in a Patient with Systemic Lupus Erythematosus.

Talaromyces marneffei is an important opportunistic pathogen mainly afflicting the HIV-infected patients, in rare instance, it could cause infection in non-HIV-infected individuals. We report a 51-year-old Chinese woman who, with histories of SLE for 14 years and disseminated talaromycosis for 4 years, occurred partial intestinal obstruction that was demonstrated to be caused by Talaromyces marneffei infection. The randomly amplified polymorphic DNA results of paraffin-embedded tissues from both the present episode and the previous infection suggested that the present infection was a recurrent.

In vitro study of low intensity ultrasound combined with different doses of PDT: Effects on C6 glioma cells.

The aim of this study was to study the effects of killing C6 glioma cells induced by hematoporphyrin monomethyl ether (HMME)-mediated sonodynamic therapy combined with photodynamic therapy (SPDT). In the SPDT group, the cells were treated with sonication at an intensity of 0.5 W/cm(2) and a frequency of 1 MHz, followed by different doses of light irradiation.

Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy.

Purpose: Our aim was to study calcium overload-induced apoptosis and its relation to reactive oxygen species (ROS) in rat C6 glioma cells after sonodynamic treatment (SDT).

Materials And Methods: Hematoporphyrin monomethyl ether (HMME) was used as the sonosensitizer. The concentration of intracellular Ca(2+) ([Ca(2+)](i)) was measured by fluorometry.

In vitro activities of erythromycin, tetracycline and levofloxacin alone and in dual combinations against ureaplasma spp.

Purpose: It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas.

Methods: The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay.

Results: TET was the most active when the antibiotics were used alone.

[Genomic sequence of hepatitis A virus L-A-1 vaccine strain].

Objective: To study the genome sequence of hepatitis A virus L-A-1 strain which has been applied for live attenuated vaccine production in China, to compare with other HAV strains, to understand some characteristics of L-A-1 strain, and to find the mechanism of attenuation and cell adaptation.

Methods: Genome fragments were prepared by antigen-capture PCR from infected cell (2BS), PCR products were cloned into T vector, sequenced and analyzed by using bioinformatics program.

Results: Analysis of the genomic sequences(nt 25-7,418) showed that the open reading frame contains 6,675 nucleotides in length encoding 2,225 amino acids.