Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CL inhibitors against SARS-CoV-2.

A series of peptidomimetic compounds containing benzothiazolyl ketone and [2.2.1] azabicyclic ring was designed, synthesized and evaluated in the hope of obtaining potent oral 3CL inhibitors with improved pharmacokinetic properties.