Publications by authors named "Jingyang Tan"
Int J Nanomedicine
May 2023
Article Synopsis
- * Researchers developed TAT-Melatonin liposomes (TAT-MT-LIPs) to combat BAC-induced dry eye disease (BAC-DED) by reducing inflammation and preserving corneal cell integrity in rats.
- * The study found that BAC triggers specific pathways leading to corneal cell death, but TAT-MT-LIPs effectively inhibited this damage by targeting mitochondrial DNA oxidation and inflammatory signaling.
Adv Healthc Mater
August 2023
Article Synopsis
- Researchers are developing new multi-hydrophobic side chain polymers (MHCPs) based on lysine oligomers to improve the loading capacity of nanoparticles for hydrophobic drugs, addressing limitations in traditional amphiphilic copolymers.
- These MHCPs form uniquely shaped nanoparticles that can effectively carry hydrophobic molecules and show significantly improved drug loading capability compared to previous methods.
- The FK506-loaded nanoparticles demonstrate greater retention on the eye surface and show superior immunosuppressive effects compared to both free FK506 and commercial eye drops in preclinical tests.
