Fisetin inhibits Typhimurium type III secretion system regulator HilD and reduces pathology .

Salmonella spp. remains a major worldwide health concern that causes significant morbidity and mortality in both humans and animals. The spread of antimicrobial resistant strains has declined the efficacy of conventional chemotherapy.

Inhibition of the Type III Secretion System of Salmonella enterica Serovar Typhimurium via Treatment with Fraxetin.

The increasingly serious problem of bacterial drug resistance has led to the development of antivirulence agents. The Salmonella enterica serovar Typhimurium pathogenicity island (SPI)-encoded type III secretion system (T3SS) and its effector proteins are important virulence factors for Typhimurium invasion and replication in host cells and for antivirulence drug screening. Fraxetin is isolated from spp.

Harmine, an inhibitor of the type III secretion system of serovar Typhimurium.

New therapeutic strategies for clinical serovar Typhimurium ( Typhimurium) infection are urgently needed due to the generation of antibiotic-resistant bacteria. Inhibition of bacterial virulence has been increasingly regarded as a potential and innovative strategy for the development of anti-infection drugs. pathogenicity island (SPI)-encoded type III secretion system (T3SS) represents a key virulence factor in Typhimurium, and active invasion and replication in host cells is facilitated by the secretion of T3SS effector proteins.

Tannic Acid Inhibits Serovar Typhimurium Infection by Targeting the Type III Secretion System.

serovar Typhimurium ( Typhimurium) is a zoonotic pathogen that can cause food poisoning and diarrhea in both humans and animals worldwide. The pathogenicity island (SPI) genes encoded type III secretion system (T3SS) is important for Typhimurium invasion and replication in host cells. Due to the increasing problem of antibiotic resistance, antibiotic treatment for clinical infection has gradually been limited.

Effects of mixed lactic acid bacteria on intestinal microbiota of mice infected with Staphylococcus aureus.

Background: The stability of intestinal microorganisms plays an important role in human health, as the intestines perform important functions in the human body. Staphylococcus aureus is a Gram-positive, facultative anaerobic bacteria, it causes human infection worldwide, and is a major pathogen that causes intestinal infection. Mixed lactic acid bacteria (LAB) may have potential in the prevention and treatment of S.

Mixed Strains Inhibit Induced Inflammation and Ameliorate Intestinal Microflora in Mice.

. is an important pathogen that causes intestinal infection. We examined the immunomodulatory function of single and mixed strains, as well as their impacts on the structure of the microbiome in mice infected with .