Publications by authors named "Jingya Kong"
Aim: To explore the local spontaneous neural activity and whole-brain functional connectivity patterns in the resting brain of acrophobia patients.
Methods: 50 patients with acrophobia and 47 healthy controls were selected for this study. All participants underwent resting-state MRI scans after enrollment.
Blood-brain barrier (BBB) impairment is related to the development of Alzheimer's disease (AD), which is dependent not only on tight junction but also on transcytosis of brain endothelial cells (BECs) in the BBB. Aging induces the decrease of ligand-specific receptor-mediated transcytosis (RMT) and the increase of non-specific caveolar transcytosis in BECs, which lead to the entry into parenchyma of neurotoxic proteins and the smaller therapeutic index in central nervous system drug delivery, further provoking neurodegenerative disease. A previous study suggests that sea-derived Antarctic krill oil (AKO) exhibits synergistic effects with land-derived nobiletin (NOB) and theanine (THE) on ameliorating memory and cognitive deficiency in SAMP8 mice.
View Article and Find Full Text PDFThe complex pathogenesis of Alzheimer's disease (AD) leads to a limited therapeutic effect; therefore, the combination of multiple bioactive ingredients may be more effective in improving AD due to synergistic effects. Based on the perspective of the sea-land combination, the effects of sea-derived Antarctic krill oil (AKO) combined with land-derived nobiletin (Nob) and L-theanine (The) on memory loss and cognitive deficiency were studied in senescence-accelerated prone 8 mice (SAMP8). The results demonstrated that AKO combined with The significantly increased the number of platform crossings in the Morris water maze test by 1.
View Article and Find Full Text PDFArticle Synopsis
- Acrophobia is a common phobia causing impairment in daily life, but its underlying brain mechanisms remain largely unclear.
- A study compared 26 acrophobic patients with 30 healthy controls using resting-state fMRI and found differences in brain activity, specifically increased ReHo in the fusiform gyrus and decreased connectivity in other brain regions among those with acrophobia.
- The findings suggest that the identified brain function abnormalities could provide insights into the neurobiological basis of acrophobia and offer targets for future interventions and preventive measures.