Pyrrolylmethylene Appended Corrorin: Peripheral Coordination and Transformation to Pyridyl Incorporated Hemiporphycene Analogue.

A pyrrolylmethylene appended corrorin was synthesized and coordinated with [Rh(CO)Cl] to afford with unique Rh-η-CC bonding in addition to the coordination of the dipyrrin-like unit and a carbonyl ligand. Further oxidation of afforded , exhibiting a hydrocorrorinone core, and it can be further transformed into pyrrolo[3,2-]pyridine incorporated hemiporphycene analogue upon treatment with HOAc. The side chain modifies the reactivity of corrorin and effectively tunes the NIR absorption of the resulting porphyrinoids.

Abbreviated MDS-UPDRS for Remote Monitoring in PD Identified Using Exhaustive Computational Search.

Background: The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) comprises 50 items, consisting of historical questions and motor ratings, typically taking around 30 minutes to complete. We sought to identify an abbreviated version that could facilitate use in clinical practice or used remotely via telemedicine.

Methods: To create an 8-item version we conducted an "exhaustive search" of all possible subsets.

Erratum to: The treatment effect of novel hGHRH homodimer to male infertility hamster.

[This corrects the article on p. 637 in vol. 22, PMID: 30402024.

The treatment effect of novel hGHRH homodimer to male infertility hamster.

Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in reproduction. To study the treatment effect of (a novel hGHRH homodimer), the infertility models of 85 male Chinese hamsters were established by intraperitoneally injecting 20 mg/kg of cyclophosphamide once in a week for 5 weeks and the treatment with or human menopausal gonadotropin (hMG) as positive control was evaluated by performing a 3-week mating experiment. 2-8 mg/kg of and 200 U/kg of hMG showed similar effect and different pathological characteristics.

Novel hGHRH homodimer promotes fertility of female infertile hamster by up-regulating ovarian GHRH receptor without triggering GH secretion.

Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. The female infertility models were formed by intraperitoneally injecting cyclophosphamide in 5-week-old Chinese hamster once in a week for 5 weeks. All the models mated with healthy male hamster in the ratio of 1:1 in the experimental 6-8th week and the couples were separated to breed in the 9-10th week.