Immunomagnetic particles exhibiting programmable hierarchical flower-like nanostructures for enhanced separation of tumor cells.

Immunomagnetic particles are extensively used for the separation of biological molecules and particles, and have exhibited great potential in many fields including biosensors, disease diagnosis and biomedical engineering. However, most immunomagnetic particles exhibit a smooth surface, resulting in a limited separation efficiency for biological particles featuring enormous surface nanostructures, such as tumor cells. Here we report flower-like immunomagnetic particles (FIMPs) prepared by streptavidin (SA)-assisted biomineralization and one-step antibody modification, and demonstrate their superior capability for highly efficient and selective separation of circulating tumor cells (CTCs).

Circulating small extracellular vesicle RNA profiling for the detection of T1a stage colorectal cancer and precancerous advanced adenoma.

It takes more than 20 years for normal colorectal mucosa to develop into metastatic carcinoma. The long time window provides a golden opportunity for early detection to terminate the malignant progression. Here, we aim to enable liquid biopsy of T1a stage colorectal cancer (CRC) and precancerous advanced adenoma (AA) by profiling circulating small extracellular vesicle (sEV)-derived RNAs.

Liquid-Like Surfaces with Enhanced De-Wettability and Durability: From Structural Designs to Potential Applications.

Liquid-like surfaces (LLSs) with dynamic repellency toward various pollutants (e.g., bacteria, oil, and ice), have shown enormous potential in the fields of biology, environment, and energy.

Bioinspired radiative cooling coating with high emittance and robust self-cleaning for sustainably efficient heat dissipation.

To overcome the overheating phenomena of electronic devices and energy components, developing advanced energy-free cooling coatings with promising radiative property seem an effective and energy-saving way. However, the further application of these coatings is greatly limited by their sustainability because of their fragile and easy contamination. Herein, it is reported that a bioinspired radiative cooling coating (BRCC) displayed sustainably efficient heat dissipation by the combination of high emittance and robust self-cleaning property.

Machine-Learning-Assisted Procoagulant Extracellular Vesicle Barcode Assay toward High-Performance Evaluation of Thrombosis-Induced Death Risk in Cancer Patients.

Venous thromboembolism (VTE) is the most fatal complication in cancer patients. Unfortunately, the frequent misdiagnosis of VTE owing to the lack of accurate and efficient evaluation approaches may cause belated medical intervention and even sudden death. Herein, we present a rapid, easily operable, highly specific, and highly sensitive procoagulant extracellular vesicle barcode (PEVB) assay composed of TiO nanoflower (TiNFs) for visually evaluating VTE risk in cancer patients.

Recent advances in bio-inspired ionic liquid-based interfacial materials from preparation to application.

Natural creatures always display unique and charming functions, such as the adhesion of mussels and the lubrication of Nepenthes, to maintain their life activities. Bio-inspired interfacial materials infused with liquid, especially for ionic liquids (ILs), have been designed and prepared to meet the emerging and rising needs of human beings. In this review, we first summarize the recent development of bio-inspired IL-based interfacial materials (BILIMs), ranging from the synthesis strategy to the design principle.

Water Spider-Inspired Nanofiber Coating with Sustainable Scale Repellency via Air-Replenishing Strategy.

To survive underwater even in severely hypoxic water for a long period, the water spider has to periodically collect and replenish air into the diving bell. Inspired by this natural air-replenishing strategy, a water spider-inspired nanofiber (WSN) coating with underwater superaerophilicity displaying excellent and sustainable scalephobic capability is prepared. Air film on the WSN coating can be well-kept and further employed as the barrier layer for scale repellence.

Sustainable scale resistance on a bioinspired synergistic microspine coating with a collectible liquid barrier.

Scale deposition, especially in the petroleum industry, has always been a serious issue because of its potential safety hazards and huge economic cost. However, conventional scale-resistant strategies based on mechanical descaling and chemical detergents can't feed the urgent demand for energy saving and environmental protection. Herein, we report a bioinspired long-term oil collectible mask (BLOCK)-a microspine coating with the synergistic effect of anti-adhesion and oil collection, displaying sustainable scale resistance towards oilfield-produced water.

Nacre-inspired underwater superoleophobic films with high transparency and mechanical robustness.

Underwater superoleophobic materials have attracted increasing attention because of their remarkable potential applications, especially antifouling, self-cleaning and oil-water separation. A limitation of most superoleophobic materials is that they are non-transparent and have limited mechanical stability underwater. Here, we report a protocol for preparing a transparent and robust superoleophobic film that can be used underwater.

Advanced Nanotechnologies for Extracellular Vesicle-Based Liquid Biopsy.

Extracellular vesicles (EVs) are emerging as a new source of biomarkers in liquid biopsy because of their wide presence in most body fluids and their ability to load cargoes from disease-related cells. Owing to the crucial role of EVs in disease diagnosis and treatment, significant efforts have been made to isolate, detect, and analyze EVs with high efficiency. A recent overview of advanced EV detection nanotechnologies is discussed here.

Evaporation-Induced rGO Coatings for Highly Sensitive and Non-Invasive Diagnosis of Prostate Cancer in the PSA Gray Zone.

The prostate-specific antigen (PSA) has been widely used for the early diagnosis of prostate cancer during routine check-ups. However, the low sensitivity of regular PSA tests in the PSA gray zone often means that patients are required to undergo further invasive needle biopsy for the diagnosis of prostate cancer, which may lead to potential overdiagnosis and overtreatment. In this study, a circulating tumor cell (CTC)-chip based on an evaporation-induced reduced graphene oxide (rGO) coating is presented, which enables a highly specific and non-invasive diagnosis of prostate cancer in the PSA gray zone.

Recent Progress of Bioinspired Scalephobic Surfaces with Specific Barrier Layers.

Bioinspired superwettable surfaces have been widely harnessed in diverse applications such as self-cleaning, oil/water separation, and liquid transport. So far, only a little work is focused on scalephobic capability of those superwettable surfaces. However, the troublesome scale deposition will inevitably be observed in our daily production and life, greatly reducing heat transfer efficiency and inhibiting the liquid transport.

Nickel-Catcher-Doped Zwitterionic Hydrogel Coating on Nickel-Titanium Alloy Toward Capture and Detection of Nickel Ions.

Nickel-titanium (NiTi) alloys show broad applicability in biomedical fields. However, the unexpected aggregation of bacteria and the corrosion of body fluid on NiTi-based medical devices often lead to the leakage of nickel ions, resulting in inevitable allergic and cytotoxic activities. Therefore, the capture and detection of nickel ions are important to avoid serious adverse reactions caused by NiTi-based medical devices.

How to Prevent Bubbles in Microfluidic Channels.

Microfluidic technology has aroused wide applications, including analytical science, diagnostic technology, and micro-/nanofabrication. However, bubbles in microfluidic channels always bring out adverse impacts such as cell damage and device malfunction. To prevent bubble formation, numerical simulation and experiments were integrated to reveal the effect of the factors including the internal structure of the channel, internal wettability, and liquid flow rate.

Nacre-Inspired Mineralized Films with High Transparency and Mechanically Robust Underwater Superoleophobicity.

Underwater superoleophobic materials have shown promising applications in various fields, especially in the highly frequent oil-spill accidents. However, the transparency and mechanical properties of existing underwater superoleophobic materials are generally mutually exclusive. In this work, a transparent and mechanically robust underwater superoleophobic film is presented by combining superspreading and biomineralization.

Photo-Irresponsive Molecule-Amplified Cell Release on Photoresponsive Nanostructured Surfaces.

Cell manipulation has raised extensive concern owing to its underlying applications in numerous biological situations such as cell-matrix interaction, tissue engineering, and cell-based diagnosis. Generally, light is considered as a superior candidate for manipulating cells (e.g.

Bioinspired Microfluidic Device by Integrating a Porous Membrane and Heterostructured Nanoporous Particles for Biomolecule Cleaning.

Mimicking the structures and functions of biological systems is considered as a promising approach to construct artificial materials, which have great potential in energy, the environment, and health. Here, we demonstrate a conceptually distinct design by synergistically combining a kidney-inspired porous membrane and natural sponge-inspired heterostructured nanoporous particles to fabricate a bioinspired biomolecule cleaning device, achieving highly efficient biomolecule cleaning spanning from small molecules to macromolecules. The bioinspired biomolecule cleaning device is a two-layer microfluidic device that integrates a polyamide porous membrane and heterostructured nanoporous poly(acrylic acid)-poly(styrene divinylbenzene) particles.

Topography-Induced Cell Self-Organization from Simple to Complex Aggregates.

Self-organization is a fundamental and indispensable process in a living system. To understand cell behavior in vivo such as tumorigenesis, 3D cellular aggregates, instead of 2D cellular sheets, have been employed as a vivid in vitro model for self-organization. However, most focus on the macroscale wetting and fusion of cellular aggregates.

Polyoxometalate-based microcrystal arrays patterned on air-grid superwettable surface.

Surface patterning of polyoxometalates (POMs) is an important step to gain functional materials and devices. However, some special requirements such as complex operation steps or strict synthesis environment greatly limit their further applications. Herein, we have employed a simple and universal strategy for patterning POM-based microcrystal arrays on air-grid superwettable surfaces.

Bio-Inspired Underwater Super Oil-Repellent Coatings for Anti-Oil Pollution.

Underwater superoleophobic surfaces have attracted great attention due to their broad applications such as anti-oil adhesion, oil capture and transportation, and oil/water separation. However, it is often fairly complex and time-consuming, involved in the construction of micro/nanostructures and the regulation of chemical compositions; there is an urgent need to develop new strategies to conquer these problems. Inspired by the strong anchoring capability and easy accessibility of plant polyphenols, we can readily and rapidly fabricate tannic acid (TA) coated copper surfaces with the excellent underwater super oil-repellent property.

Electrochemical Responsive Superhydrophilic Surfaces of Polythiophene Derivatives towards Cell Capture and Release.

Highly efficient cell capture and release with low background are urgently required for early diagnosis of diseases such as cancer. Herein, we report an electrochemical responsive superhydrophilic surface exhibiting specific cell capture and release with high yields and extremely low nonspecific adhesion. Through electrochemical deposition, 3-substituted thiophene derivatives are deposited onto indium tin oxide (ITO) nanowire arrays with 4-n-nonylbenzeneboronic acid (BA) as dopant, fabricating the electrochemical responsive superhydrophilic surfaces.

Protein-mediated anti-adhesion surface against oral bacteria.

Biomedical materials, such as orthopedic biomaterials, have a great impact on improving life quality and self-esteem of human beings. However, the usage of fixed appliances during dental treatment often increases the difficulty of oral cleaning and enlarges the adhesion opportunity of oral bacteria. Furthermore, the existing anti-adhesion coatings, such as polyethylene glycol derivatives and zwitterionic polymers, have not been universally accepted in the oral environment due to their intrinsic problems.

Superwettable microchips with improved spot homogeneity toward sensitive biosensing.

The high-quality spots in microchips are prerequisites for sensitive and accurate detection of biomarkers. In this work, the superwettable micropattern was constructed by introducing superhydrophilic microwells onto a superhydrophobic substrate. The sample can distribute homogeneously within the well-designed superhydrophilic microwells after droplet evaporation and form homogeneous deposit spots, which can be ascribed to the enhanced Marangoni effect in superwettable micropattern and the suppressed outward flow by 3D nanodendritic silica structure.