The Benefits of Self-Transcendence: Examining the Role of Values on Mental Health Among Adolescents Across Regions in China.

As one of the foundations of existential positive psychology, self-transcendence can bring positive intrapersonal and interpersonal outcomes, especially in the COVID-19 era in which people are suffering huge mental stress. Based on Schwartz's theory of human basic values, the current study combines variable-centered and person-centered approaches to examine the relationships between adolescents' values and mental health across two regions in China. The results generally showed that (1) both self-enhancement and conservation values were positively correlated with depression and loneliness, while both self-transcendence and openness to change values negatively correlated with depression and loneliness.

Silencing of LncRNA SNHG16 Downregulates Cyclin D1 (CCND1) to Abrogate Malignant Phenotypes in Oral Squamous Cell Carcinoma (OSCC) Through Upregulating miR-17-5p.

Background: Targeting the long non-coding RNAs (LncRNAs)-microRNAs (miRNAs)-mRNA competing endogenous RNA (ceRNA) networks has been proved as an effective strategy to treat multiple cancers, including oral squamous cell carcinoma (OSCC). Based on this, the present study identified a novel LncRNA SNHG16/miR-17-5p/CCND1 signaling pathway that played an important role in regulating the pathogenesis of OSCC.

Methods: The expression levels of cancer-associated genes were examined by Real-Time qPCR and Western Blot at transcriptional and translated levels, respectively.

Porous carbon framework derived from N-rich hypercrosslinked polymer as the efficient metal-free electrocatalyst for oxygen reduction reaction.

The development of high-performance non-precious metal electrocatalysts is of great importance for construction of next generation fuel cells. Herein, we report for the first time the creation of new metal-free porous carbon framework catalysts derived from N-rich hypercrosslinked polymers (HCPs) using pyrrole as building blocks for oxygen reduction reaction (ORR) (denoted as PCF-HCPs). The PCF-HCPs obtained at the pyrolysis temperature of 900 °C (PCF-HCP-900), displayed outstanding catalytic activity towards the ORR compared with other PCF-HCPs pyrolysis temperature.

Target DNA mutagenesis-based fluorescence assessment of off-target activity of the CRISPR-Cas9 system.

The RNA-guided CRISPR/Cas9 system could cleave double-stranded DNA at the on-target sites but also induce off-target mutations in unexpected genomic regions. The base-pairing interaction of sgRNA with off-target DNA was still not well understood and also lacked a direct cell-based assay. Herein we developed a fast target DNA mutagenesis-based fluorescence assay to directly detect the Cas9 activity at different off-target sites in living cells.

CRISPR RNA Array-Guided Multisite Cleavage for Gene Disruption by Cas9 and Cpf1.

To achieve multisite-targeting-based DNA cleavage simultaneously, we designed two kinds of CRISPR RNA arrays by fusing four single guide RNAs (sgRNAs for Cas9 or crRNAs for Cpf1) with uncleavable RNA linkers (CRISPRay). The CRISPRay could operate on four adjacent target sites to cleave target DNA in a collaborative manner. Two CRISPR RNA arrays demonstrated robust inactivation of the firefly luciferase gene in living cells.

[Concurrent nodal and extranodal lymphoma misdiagnosed as metastatic gingival carcinoma: A case report].

Early diagnosis of malignant lymphoma is often difficult since the clinical manifestation of the lymphoma occurred in the maxillofacial region is very similar to that of the squamous cell carcinoma. When the pathological diagnosis is not clear, the surgeon is easy to misdiagnose and lead to mistreatment. A patient visited the Affiliated Haikou Hospital of Xiangya School of Medicine, Central South Universily for gingival mass with an ipsilateral submaxillary enlargement.