VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγNF-κB signaling pathway.

Neuroinflammation, characterized by microglial activation and the subsequent secretion of inflammatory cytokines, plays a pivotal role in neurodegenerative diseases and brain injuries, often leading to neuronal damage and death. Alleviating neuroinflammation has thus emerged as a promising strategy to protect neurons and ameliorate neurodegenerative disorders. While peroxisome proliferator-activated receptor gamma (PPARγ) agonists have demonstrated potential therapeutic actions on neuroinflammation, their prolonged use, such as with rosiglitazone, can lead to cardiac risks and lipid differentiation disorders.

Interactions and quantification of multiple influencing factors on cadmium accumulation in soil-rice systems at a large region.

The accumulation of Cd in soil-rice systems at a large region is often extremely complicated due to environmental heterogeneity and the interactions of multiple influencing factors. However, the interactive effects and quantification of the contributions of influencing factors on Cd accumulation in large regions remain unclear. In this study, conditional inference trees and random forest analysis were used to identify the interactions of various factors (soil properties, topography and demographic-economic), and quantify their contributions to Cd accumulation in soil-rice systems of Sichuan-Chongqing region, China.

[Cd Pollution and Safe Planting Zoning in Paddy Soils: A Case Study in a District of Chongqing].

Rice has a strong ability to accumulate Cd in soil, and it is of great significance to study Cd pollution and safe planting zoning in paddy soils. In this work, 300 sets of paddy soil-rice samples were simultaneously collected in 22 towns in a District of Chongqing, and soil pH, soil total and available Cd contents, and brown rice Cd contents were determined. Soil Cd pollution was assessed using the geoaccumulation index, bioconcentration factor, and the single-factor pollution index.