Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders.

Treatment of diseases of oxidative stress through activation of the antioxidant nuclear factor E2-related factor 2 (NRF2) is limited by systemic side effects. We chemically functionalize the NRF2 activator monomethyl fumarate to require Baeyer-Villiger oxidation for release of the active drug at sites of oxidative stress. This prodrug reverses chronic pain in mice with reduced side effects and could be applied to other disorders of oxidative stress.

Self-Healing and Shear-Stiffening Electrodes for Wearable Biopotential Sensing and Gesture Recognition.

The achievement of flexible skin electrodes for dynamic monitoring of biopotential is one of the challenging issues in flexible electronics due to the interference of large acceleration and heavy sweat that influence the stability of skin-electrode interfaces. This work presents materials and techniques to achieve self-healing and shear-stiffening electrodes and an associated flexible system that can be used for multichannel biopotential measurement on the skin. The electrode that is based on a composite of silver (Ag) flakes, Ag nanowires, and polyborosiloxane offers an electrical conductivity of 9.

Urolithin B inhibits the differentiation of M1 macrophages and relieves the inflammation around the implants under osteoporosis via down-regulating the phosphorylation of VEGFR2.

The inflammation causes the destroyed osseointegration at the implant-bone interface, significantly increasing the probability of implant loosening in osteoporotic patients. Currently, inhibiting the differentiation of M1 macrophages and the inflammatory response could be a solution to stabilize the microenvironment of implants. Interestingly, some natural products have anti-inflammatory and anti-polarization effects, which could be a promising candidate for stabilizing the implants' microenvironment in osteoporotic patients.

Ultrafast Knock-Off Li Diffusion and Subtle Structural Evolution of LiVO Anode in Lithium-Ion Batteries.

LiVO, a lithiation product derived from the LiVO cathode, has emerged as a promising intercalation-type anode material, boasting a theoretical capacity of 256 mA h g. Through a comprehensive combination of experimental and theoretical approaches, we demonstrate its capability to intercalate a substantial amount of Li at extremely high rates. Experimental findings reveal that LiVO exhibits outstanding high-rate capability (with a specific capacity of 152 mA h g, 60% of the theoretical capacity at 40 C) and exceptional cyclability (with a capacity retention of 80% after 11,000 cycles at 20 C).

A New Gramicidin S Analogue with Potent Antibacterial Activity and Negligible Hemolytic Toxicity.

Antibiotic resistance is an urgent threat to global health, with the decreasing efficacy of conventional drugs underscoring the urgency for innovative therapeutic strategies. Antimicrobial peptides present as promising alternatives to conventional antibiotics. Gramicidin S is one such naturally occurring antimicrobial peptide that is effective against , with a minimum inhibitory concentration (MIC) of 4 μg/mL (3.

Symptoms experienced after transcatheter arterial chemoembolization in patients with primary liver cancer: A network analysis.

Objective: This study aimed to establish a symptom network for patients with primary liver cancer posttranscatheter arterial chemoembolization (TACE), identifying core and bridge symptoms. The goal is to provide a foundation for precise and comprehensive nursing interventions.

Methods: A total of 1207 post-TACE patients were included using a consecutive sampling method.

Cytochrome P4503A4 gene polymorphisms guide safe sufentanil analgesic doses in pregnant Chinese mothers: a multicenter, randomized, prospective study.

Background: Sufentanil and ropivacaine when used as epidural anesthetics effectively reduce maternal pain during labor. From previous reports, rs2242480 single nucleotide polymorphisms (SNPs) can alter sufentanil metabolism, which affects analgesic efficacy.

Methods: We randomly divided 573 eligible mothers into groups A and B (in a 1 : 3 ratio).

Full Potential Catalysis of CoNiP-V/CNT with Phosphorus Vacancies for LiS Deposition/Decomposition and S/LiS (3 ≤ ≤ 8) Conversion in Li-S Batteries.

The slow kinetics of polysulfide conversions hinders the commercial progress of Li-S batteries. The introduction of high-efficiency catalysts accelerates heterogeneous reactions and enhances the utilization of S. The full potential of the CoNiP-V/CNT-modified separator catalyzes the all-process reactions of the S electrode and increases the rates and cycling lives of the batteries.

Unveiling microplastics from zippers: Characterisation and visualisation through Raman imaging analysis.

Microplastics have emerged as a global concern due to the increased plastic contamination found in a variety of sources. Herein we unveil microplastics released from plastic zippers that can generally be found in our clothes and textiles. We first employ a scanning electron microscope (SEM) to visualise the scratches developed on the zipper teeth and the derived particles.

Exploring Photoswitchable Binding Interactions with Small-Molecule- and Peptide-Based Inhibitors of Trypsin.

The ability to photochemically activate a drug, both when and where needed, requires optimisation of the difference in biological activity between each isomeric state. As a step to this goal, we report small-molecule- and peptide-based inhibitors of the same protease-trypsin-to better understand how photoswitchable drugs interact with their biological target. The best peptidic inhibitor displayed a more than fivefold difference in inhibitory activity between isomeric states, whereas the best small-molecule inhibitor only showed a 3.

Ratiometric colorimetric detection of fluoride ions using a schiff base sensor: enhancing selectivity and sensitivity for naked-eye analysis.

A Schiff base receptor with an active -NH group was designed and synthesized for the selective and sensitive colorimetric detection of inorganic fluoride (F) ions in an aqueous medium. The sensitivity of the receptor for F ions was enhanced by the influence of two electron-withdrawing -NO groups at ortho and para positions which result in a vivid color change. The receptor underwent a remarkable color change from light yellow to violet, enabling naked-eye detection of F ions without the need for spectroscopic equipment.

The relationships between organizational culture and thriving at work among nurses: The mediating role of affective commitment and work engagement.

Aim: Guided by the social embeddedness model of thriving at work, this paper explores how nursing organizational culture, work engagement and affective commitment affect nurses' thriving at work.

Background: Thriving at work has implications for better employee and organization outcomes. The antecedents of thriving at work among the nursing population needs to be expanded by analysing the cross-level impact of organizational and individual characteristics.

2,3-Diaminophenazine@carbon felt with chemical grafting amide bonds as an electrode in lithium-ion batteries.

Grafting organic molecules onto an insoluble matrix is an effective way to improve the electronic conductivity and insolubility in electrolyte of organic electrode materials. The active group of CN in DAP@C composites synthesized by chemical grafting of 2,3-diaminophenazine (DAP) with carbon felt through amide bonds (-CO-NH-) displays excellent electrochemical behavior.

Long Noncoding RNA lncRHL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis.

Dysregulation of hepatic VLDL secretion contributes to the pathogenesis of metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia. Accumulating evidence has suggested that long noncoding RNAs (lncRNAs) had malfunctioning roles in the pathogenesis of NAFLD. However, the function of lncRNAs in controlling hepatic VLDL secretion remains largely unillustrated.

High Lithium Ion Flux of Integrated Organic Electrode/Solid Polymer Electrolyte from In Situ Polymerization.

The high interface impedance between inorganic material electrodes and solid electrolytes results in a high Li diffusion energy barrier, which limits the electrochemical performance of active materials. To solve this issue, an integrated configuration of organic active material electrode-solid polymer electrolyte (SPE) is synthesized via in situ polymerization. In the integrated aminoanthraquinone-solid polymer electrolyte (AQ-SPE), the naphthalene urethane bond acts as a bridge that links the organic material electrode and the SPE and acts as a channel for Li transport at the electrode/SPE interface.

Electrochemical preparation of nano/micron structure transition metal-based catalysts for the oxygen evolution reaction.

Electrochemical water splitting is a promising technology for hydrogen production and sustainable energy conversion, but the existing electrolytic cells lack a sufficient number of robust and highly active anodic electrodes for the oxygen evolution reaction (OER). Electrochemical synthesis technology provides a feasible route for the preparation of independent OER electrodes with high utilization of active sites, fast mass transfer, and a simple preparation process. A comprehensive review of the electrochemical synthesis of nano/microstructure transition metal-based OER materials is provided.

How does overall hospital satisfaction relate to patient experience with nursing care? a cross-sectional study in China.

Objective: To determine how patient experience with nursing care influence patient satisfaction with overall hospital services.

Design: This was a cross-sectional study.

Setting: Inpatients were consecutively recruited at the national hospital (with 2000 beds) in Shanghai, China.

Evaluation of Psychosocial Pathways to Family Adaptation of Chinese Patients With Liver Cancer Using the McCubbin's Family Resilience Model.

With the prolonged survival time of patients with liver cancer, these families may face tremendous pressure and development dilemmas that can easily lead to family adaptation crises. Correspondingly, family adaptation crises adversely affect the quality of life of patients and family members. Basing on McCubbin's resilience model of family stress, adjustment, and adaptation, and considering the key factors affecting family resilience based on a review of literature, this study involved a construction of a family adaptation influencing factors model in Chinese liver cancer patients, which was then verified and revised.

Mechanically Induced Switching between Two Discrete Conductance States: A Potential Single-Molecule Variable Resistor.

The fabrication of solid-state single-molecule switches with high on-off conductance ratios has been proposed to advance conventional technology in areas such as molecular electronics. Herein, we employed the scanning tunneling microscope break junction (STM-BJ) technique to modulate conductance in single-molecule junctions using mechanically induced stretching. Compound possesses two dihydrobenzothiophene (DHBT) anchoring groups at the opposite ends linked with rigid alkyne side arms to form a gold-molecule-gold junction, while contains 4-pyridine-anchoring groups.

Progress in Solid Polymer Electrolytes for Lithium-Ion Batteries and Beyond.

Solid-state polymer electrolytes (SPEs) for high electrochemical performance lithium-ion batteries have received considerable attention due to their unique characteristics; they are not prone to leakage, and they exhibit low flammability, excellent processability, good flexibility, high safety levels, and superior thermal stability. However, current SPEs are far from commercialization, mainly due to the low ionic conductivity, low Li transference number (t ), poor electrode/electrolyte interface contact, narrow electrochemical oxidation window, and poor long-term stability of Li metal. Recent work on improving electrochemical performance and these aspects of SPEs are summarized systematically here with a particular focus on the underlying mechanisms, and the improvement strategies are also proposed.

Water-Sintered Transient Nanocomposites Used as Electrical Interconnects for Dissolvable Consumer Electronics.

Rapid development of electronic technology shortens the development time for new products and accelerates the obsolescence of consumer electronics, resulting in the explosive growth of electronic waste that is difficult to recycle and hazardous to the environment and human health. Transient electronics that can dissolve in water may potentially be adopted to tackle the issues of electronic waste; however, promising approaches to yield large-scale and high-performance transient consumer electronics have not yet been developed. Here, the joint effect of galvanic corrosion and redeposition has been utilized to develop bimetallic transient nanocomposites, which can be printed and water-sintered to yield high-performance transient PCB circuits with excellent electrical conductivity and mechanical robustness.

Novel data-driven two-dimensional Q-learning for optimal tracking control of batch process with unknown dynamics.

In view that the previous control methods usually rely too much on the models of batch process and have difficulty in a practical batch process with unknown dynamics, a novel data-driven two-dimensional (2D) off-policy Q-learning approach for optimal tracking control (OTC) is proposed to make the batch process obtain a model-free control law. Firstly, an extended state space equation composing of the state and output error is established for ensuring tracking performance of the designed controller. Secondly, the behavior policy of generating data and the target policy of optimization as well as learning is introduced based on this extended system.

Temperature-Dependent Tunneling in Furan Oligomer Single-Molecule Junctions.

Two commonly observed charge transport mechanisms in single-molecule junctions are coherent tunneling and incoherent hopping. It has been generally believed that tunneling processes yield temperature-independent conductance behavior and hopping processes exhibit increasing conductance with increasing temperature. However, it has recently been proposed that tunneling can also yield temperature-dependent transport due to the thermal broadening of the Fermi energy of the contacts.