Publications by authors named "Jingxi Duan"
Article Synopsis
- Frailty, cognitive decline, and depression frequently occur together in older adults, but it's unclear how they interact.
- A study involving 1362 older adults found that frailty significantly raises the risk of depression, regardless of cognitive performance levels.
- The findings suggest that frailty affects depression independently of cognitive decline, highlighting the need for more extensive research on this connection.
Background: Cognitive decline and neuropsychiatric symptoms (NPS) are main clinical manifestations in Alzheimer disease (AD). It is unclear whether the link between specific NPS and cognitive domains exists in AD or mild cognitive impairment (MCI). Our study aimed to examine the association between specific cognitive domain and NPS in AD and MCI, and to evaluate whether this association showed variety in different stages of cognitive impairment.
View Article and Find Full Text PDFBackground: Insomnia is a major public health problem affecting older people. This study aimed to investigate the prevalence and clinical risk factors of insomnia in a representative sample of Chinese elderly (≥ 60 years) in Chongqing.
Methods: A cross-sectional study based on comprehensive geriatric assessment was conducted from January 2013 to February 2014.
Headache is a common problem among the population, many factors may impact the headache characteristics and medical consultation behaviors in different age groups. The purpose of this study was to evaluate the clinical characteristics and the diagnosis and treatment status of headaches in elderly patients hospitalized in a gerontologic department. Consecutive patients hospitalized in the Department of Gerontology eligible for this study were registered.
View Article and Find Full Text PDFVascular risk factors and mild cognitive impairment in the elderly population in Southwest China.
Am J Alzheimers Dis Other Demen
May 2014
Objectives: Increasing evidence has demonstrated that vascular risk factors (VRFs) contribute to cognitive impairment in the elderly population. Prevention and administration of VRFs can be a vital strategy for delaying cognitive impairment. This study aimed to determine the impact of VRFs on cognitive function of the aged people from Chongqing, Southwest China.
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- The study investigates the relationship between HUMMR (a regulator of mitochondrial function) and mitochondrial dysfunction in Alzheimer's disease (AD) using APP/PS1 double transgenic mice as a model.
- Researchers analyzed HUMMR expression and mitochondrial morphology in the hippocampus and cortex of these mice, comparing them to wild-type controls.
- Findings revealed mitochondrial damage in the transgenic mice but no significant difference in HUMMR levels, suggesting that HUMMR may not be a major factor in mitochondrial dysfunction associated with AD.
Purpose: The transforming growth factor β (TGF-β) signaling pathway is involved in the epileptogenesis. Sorting Nexin 25 (SNX25) has been recently proposed to modulate TGF-β signaling through endosomal sorting of TGF-β receptors for lysosomal degradation. The aim of the present study was to determine the expression pattern of SNX25 in brains of epilepsy patients and in animal model of epilepsy.
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