Publications by authors named "Jingwei Miao"
Article Synopsis
- Endothelial dysfunction (ED) is a critical factor in worsened health outcomes for diabetics, spurring research into treatments like fenugreek, a common edible plant known for its diabetes management benefits.
- The study examined fenugreek's effects on ED using a 70% ethanol extract analyzed for its chemical composition, identifying 49 beneficial compounds like flavonoids and saponins.
- Results from tests on diabetic mice and rat aortas showed that fenugreek improved ED by downregulating arginase 1 (Arg1), which enhanced nitric oxide production, suggesting a mechanism where fenugreek reduces Arg activity to protect vascular health.
Background/objective: SSS07, a humanized rabbit monoclonal antibody, can selectively block human tumor necrosis factor-α (TNF-α). The objective of this study was to assess the safety, tolerability, and relative immunogenicity of SSS07 after multiple single subcutaneous (SC) doses in healthy volunteers.
Methods: A total of 71 healthy volunteers were randomized to six sequential ascending-dose groups (5, 15, 30, 50, 75, and 100 mg), and except for the 100 mg group that only had one subject who received a placebo, all of the other groups included two placebo-control subjects.
Objective: This meta-analysis was performed to investigate hyperlipidemia in patients with carcinoma treated with vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor (VEGFR) inhibitors.
Methods: We searched for eligible phase II and III studies using PubMed and Embase databases. We then summarized reported occurrences of hyperlipidemia in patients with different cancers.
Previous studies demonstrated that the loss of function of the CDKN2A/p16/INK4A gene is mainly caused by the hypermethylation of CDKN2A, however, whether or not it is associated with the incidence and clinicopathological characteristics of endometrial carcinoma (EC) remains unclear. In this study, we conducted a meta-analysis aiming to comprehensively assess the role of CDKN2A hypermethylation in the pathogenesis of EC. A detailed literature search was made to identify the related research publications.
View Article and Find Full Text PDF[Effect of nano-granule titanium films on synthesis of osteoblasts].
Hua Xi Kou Qiang Yi Xue Za Zhi
December 2009
Objective: To compare the synthetic ability of osteoblasts on the surface of different nano-granule titanium films and investigate the correlation between nanophase titanium films and cellular biocompatibility.
Methods: Four different nano-granule titanium films were produced by direct current magnetron sputtering, at ambient, 100 degrees C, 250 degrees C, 380 degrees C substrate temperature, respectively. Rat osteoblasts were seeded on the surface of four treated groups of titanium film samples and non-treated Ti sample(control group).
[Construction of nano-granule titanium film and study of its surface topography].
Hua Xi Kou Qiang Yi Xue Za Zhi
August 2009
Objective: To construct four different micro- and nano-phase titanium film models and investigate the characteristics of their surface micro-topography.
Methods: Four different titanium films were prepared on commercial titanium discs, by direct current magnetron sputtering, at ambient, 100, 250, 380 degrees C substrate temperature, respectively. Their surface topography and crystal sizes were investigated using atomic force microscope (AFM) and X-ray diffraction (XRD).