PUS1 facilitates cell migration in clear cell renal cell carcinoma through the promotion of mRNA pseudouridylation and the stabilization of the SMOX gene.

Clear cell renal cell carcinoma (ccRCC) is a highly aggressive malignancy characterized by its propensity for metastasis. Pseudouridine synthase 1 (PUS1), an enzyme involved in RNA modification, has been implicated in cancer progression, but its role in ccRCC remains unclear. This study investigates PUS1's role in ccRCC and evaluates its potential as a prognostic biomarker and therapeutic target.

iBitter-GRE: A Novel Stacked Bitter Peptide Predictor with ESM-2 and Multi-View Features.

Accurate identification of bitter peptides is essential for research. Although models using sequence information have evolved in the context of bitter peptides, there is still room for improvement in their predictive performance. In the present study, we introduced a novel predictive tool, iBitter-GRE, designed to improve the accuracy of bitter peptide identification.

Machine learning identification of a novel vasculogenic mimicry-related signature and FOXM1's role in promoting vasculogenic mimicry in clear cell renal cell carcinoma.

Background: Clear Cell Renal Cell Carcinoma (ccRCC), the predominant subtype of renal cell carcinoma (RCC), ranks among the most common malignancies worldwide. Vasculogenic mimicry (VM) plays a pivotal role in tumor progression, being closely linked with heightened chemoresistance and adverse prognosis in cancer patients. Nonetheless, the broader impact of vasculogenic mimicry-related genes (VRGs) on ccRCC patient prognosis, tumor microenvironment characteristics, and treatment response remains incompletely understood.

Photonic crystal fiber based on graphene surface plasmon resonance for high-sensitivity terahertz refractive index sensing.

A photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) with a graphene coating on the cladding is designed for refractive index (RI) detection in the range of 0.3-0.5 THz, especially for liquid bioanalytical sensing.

Simulation analysis of a photonic crystal fiber refractive index sensor based on a double-layer film structure and surface plasmon resonance technology.

A photonic crystal fiber surface plasmon resonance sensor based on a double-layer membrane structure is designed and analyzed. In the simple sensing structure with only one air hole size, and Au layers with specific thicknesses are sequentially coated on the optical fiber to form a double-layer structure. The sensing characteristics of the double-layer membrane structure are studied by the finite element method.

Double-formant PCF-SPR refractive index sensor with ultra-high double-peak-shift sensitivity and a wide detection range.

A dual-resonance-peak photonic crystal fiber-surface plasmon resonance (PCF-SPR) refractive index (RI) sensor is designed for different wavelength ranges. The first resonance peak of the sensor is distributed in the wavelength range of 700-2350 nm, while the second peak is distributed in the range of 2350-5550 nm. In addition to detecting analytes using the full spectrum of constraint losses (CLs), it is also possible to use a single resonance peak to achieve the detection of analytes.

Highly sensitive surface plasmon resonance sensor based on the anti-resonant fiber with six nested tubes.

On the heels of the continuous development of optical fiber sensing technology, optical fiber sensors based on surface plasmon resonance (SPR) have attracted widespread attention. Herein, an SPR sensor based on the six nested anti-resonant fiber (ARF) is designed and analyzed by the finite element method (FEM). All the structural parameters are optimized to achieve high-sensitivity liquid refractive index detection.

Symmetrical dual-D and dual-core single-mode fiber surface plasmon resonance liquid sensor.

A symmetrical dual-D and dual-core single-mode fiber surface plasmon resonance (SPR) liquid sensor is designed for biological detection. The dual-core design optimizes the transmission path, improves the momentum matching between free electrons and photons, and facilitates bidirectional coupling, consequently amplifying the SPR effect and enabling sensitive monitoring of the refractive index changes of biological solutions. In this structure, a gold wire is placed in the middle of the polished surface of the double-D-shaped single-mode fiber (SMF) to produce high-quality free electrons and promote the mode-coupling excitation of the SPR effect.

Ultra-high sensitivity photonic crystal fiber sensor based on dispersion turning point sensitization of surface plasmonic polariton modes for low RI liquid detection.

A surface plasmon resonance (SPR) sensor composed of photonic crystal fibers (PCFs) is designed for the detection of low-concentration liquids. The excellent sensing properties are attributed to the sensitivity enhancement at the dispersion turning point (DTP) of the surface plasmon polariton (SPP) modes. The sensor consists of two identical and structurally simple D-shaped PCFs together with a plasmonic thin film coated on the polished surface in direct contact with the analyte.

Optical switching with high-Q Fano resonance of all-dielectric metasurface governed by bound states in the continuum.

The discovery of bound states in the continuum (BIC) of optical nanostructures has garnered significant research interest and found widespread application in the field of optics, leading to an attractive approach to achieve high-Q (Quality factor) Fano resonance. Herein, an all-dielectric metasurface consisting of four gallium phosphide (Gap) cylinders on the MgF substrate is designed and analyzed by the finite element method (FEM). By breaking the symmetry of the plane, specifically by moving the two cylinders to one side, it is possible to achieve a transition from the symmetry-protected BIC to quasi-BIC.

The SRC/NF-κB-AKT/NOS3 axis as a key mediator of Kaempferol's protective effects against oxidative stress-induced osteoclastogenesis.

Background: Osteoclasts are integral to the advancement of osteoporosis (OP), and their generation under conditions of oxidative stress (OS) involves various pathways. However, the specific mechanism through which the natural antioxidant kaempferol (KAE) mitigates the influence of OS on osteoclasts remains somewhat uncertain. This study aims to evaluate the effect of KAE on osteoclast formation under OS and explore its possible mechanism.

From waste to wonder: exploring the hypoglycemic and anti-oxidant properties of corn processing by-products.

The industrial processing of corn ( L.) generates by-products such as corn silk, straw peels, and straw core, which contribute to adverse environmental impacts. Our study aimed to investigate sustainable approaches for mitigating these effects by evaluating the hypoglycemic potential and mechanisms of ethyl acetate fractions derived from these corn derivatives.

Mechanisms of Zhixiao Tang on Anti-Inflammatory Multiple Targets and Multiple Components: Metabonomics Combined with Database Mining Technology.

Purpose: Zhixiao Tang (ZXT), a traditional Chinese compound prescription, has been used clinically to treat pneumonia in China. However, the underlying mechanism of ZXT treatment in pneumonia is still unclear. The present study aimed to reveal the potential mechanism of ZXT in pneumonia using a strategy combining metabolomics and network pharmacology.

High-sensitivity dual U-shaped PCF-SPR refractive index sensor for the detection of gas and liquid analytes.

A dual U-shaped photonic crystal fiber (PCF) biochemical sensor based on surface plasmon resonance (SPR) is designed for the simultaneous detection of gas and liquid analytes, and the properties are analyzed by the full vector finite element method (FEM). SPR is excited by placing gold nanowires on the inner surface of the U-shaped device. In this technique, the traditional metal deposition process can be replaced, subsequently reducing the difficulty and complexity of actual production and improving the phase matching between the basic mode and plasmonic modes.

High FOM PCF-SPR refractive index sensor based on MgF-Au double-layer films.

A simple twin-core D-shape photonic crystal fiber sensor based on surface plasmon resonance (SPR) is designed for the measurement of refractive indices (RI). The twin-core D-shape structure enhances the SPR effect, and the -Au dual-layer film narrows the linewidth in the loss spectrum, consequently improving both the sensitivity and figure of merit (FOM). The properties of the sensor are analyzed by the finite element method.

Exploring Asthma Mechanism of Belamcanda Chinensis by "Dose-effect Weighted Coefficient" Network Pharmacology and Experiment Validation.

Background: Asthma is a chronic inflammatory disease of the airways that seriously endangers human health. Belamcanda chinensis (BC), a traditional Chinese medicine, has been used to counteract asthma as it has been shown to possess anti-inflammatory and regulatory immunity properties.

Objective: The study aimed to investigate the mechanisms of action of BC in the treatment of asthma; a "dose-effect weighted coefficient" network pharmacology method was established to predict potential active compounds.

Integrated cell metabolomics and network pharmacology approach deciphers the anti-testosterone deficiency mechanisms of Bushen Zhuanggu Tang.

Testicular dysfunction is distinguished by a deficiency in testosterone levels, which can be attributed to the occurrence of oxidative stress injury in Leydig cells. The empirical prescription known as Bushen Zhuanggu Tang, developed by a highly experienced traditional Chinese medicine practitioner with six decades of clinical expertize, aligns with the traditional Chinese medicine principle of "kidney governing bone". Researchers have demonstrated that the administration of BSZGT can effectively enhance testosterone production.

Surface plasmon resonance sensor composed of micro-nano optical fibers for high-sensitivity refractive index detection.

Spurred by the continuous development of surface plasmon resonance (SPR) technology, optical fiber sensors based on SPR have become a research hotspot. Although single-mode fibers (SMFs) are simple and easy to manufacture, the sensitivity is quite poor. On the other hand, even though photonic crystal fibers (PCFs) and anti-resonant fibers (ARFs) can achieve high-sensitivity detection and the wavelength sensitivity is tens of times that of SMFs, they are complex and difficult to produce.

Anti-resonant fiber with high-resistivity silicon for THz wave transmission.

A novel anti-resonant fiber for low-loss terahertz waveguides is proposed and analyzed. The terahertz fiber uses high-resistivity silicon as the bulk material and nine nested double-layer concentric circular tubes in the cladding to reduce propagation losses. The effects of the geometric parameters on the propagation characteristics are analyzed by the finite element method.

Relay Copper-Catalyzed Synthesis of Imidazo[1,5-]pyridine Scaffolds from Phenylalanine and Halohydrocarbon.

An efficient and straightforward strategy to synthesize imidazo[1,5-]pyridine compounds from phenylalanine and halohydrocarbon has been successfully developed. The protocol features a relay copper-catalyzed reaction involving intermolecular C-O coupling and intramolecular C-N cyclization, providing an approach to access a diverse range of imidazo[1,5-]pyridine derivatives with unique aza quaternary carbon centers.

Double-ring-disk hybrid nanostructures with slits for electric field enhancement.

Although noble metal nanoantennas have distinctive optical properties and local electric field enhancement, considerable non-radiative ohmic losses occur at the optical frequencies, consequently creating significant absorption and unwanted heating. Combining the plasmon mode of metal nanoantennas with the anapole mode of high refractive index dielectric materials offers a promising alternative to increase the electric field strength with minimal loss. Herein, a silicon disk with slots and two Au rings with a coupling mechanism are described.

Effects of different cladding materials on orbital angular momentum modes propagating in photonic crystal fibers.

With the development of orbital angular momentum (OAM) photonic crystal fibers (PCFs) for more efficient communication, fiber claddings are important to the performance. In this paper, the influence of and four new optical materials, which are amethyst, SSK2, SF11, and LaSF09, as cladding materials, on the OAM mode characteristics is studied based on a common PCF for OAM transmission. In addition, the effective index difference, dispersion, confinement loss, and other properties of OAM modes transmitted in the five materials are derived by the finite element method.

Design of optical anapole modes of all-dielectric nanoantennas for SERS applications.

To obtain large electric field enhancement while mitigating material losses, an all-dielectric nanoantenna composed of a heptamer and nanocubes is designed and analyzed. A numerical simulation by the finite element method reveals that the nanoantenna achieves the optical electric anapole modes, thereby significantly enhancing the coupling between different dielectrics to further improve the near-field enhancement and spontaneous radiation. Field enhancement factors |/ | of 3,563 and 5,395 (AM1 and AM2) and a Purcell factor of 3,872 are observed in the wavelength range between 350 and 800 nm.