Publications by authors named "Jinguk Jeong"
Article Synopsis
- The study examines how N-glycosylation affects T cell function, specifically focusing on exhausted CD8 T cells in a mouse model of colon cancer.
- Researchers discovered that exhausted T cells reduce levels of the oligosaccharyltransferase complex critical for N-glycan transfer, leading to a decline in their antitumor activity.
- By restoring this complex, they were able to enhance IFN-γ production and reduce CD8 T cell exhaustion, suggesting that modifying glycosylation could be a potential strategy for cancer immunotherapy.
Activated Foxp3 regulatory T (Treg) cells differentiate into effector Treg (eTreg) cells to maintain peripheral immune homeostasis and tolerance. T cell receptor (TCR)-mediated induction and regulation of store-operated Ca entry (SOCE) is essential for eTreg cell differentiation and function. However, SOCE regulation in Treg cells remains unclear.
View Article and Find Full Text PDFThe survival of motor neuron (SMN) protein is a major component of the pre-mRNA splicing machinery and is required for RNA metabolism. Although SMN has been considered a fundamental gene for the central nervous system, due to its relationship with neuromuscular diseases, such as spinal muscular atrophy, recent studies have also revealed the requirement of SMN in non-neuronal cells in the peripheral regions. Here, we report that the fibro-adipogenic progenitor subpopulation expressing Dpp4 (Dpp4+ FAPs) is required for the neuromuscular system.
View Article and Find Full Text PDFHematopoiesis occurs within a unique bone marrow (BM) microenvironment, which consists of various niche cells, cytokines, growth factors, and extracellular matrix components. These multiple components directly or indirectly regulate the maintenance and differentiation of hematopoietic stem cells (HSCs). Here we report that BAP1 in BM mesenchymal stromal cells (MSCs) is critical for the maintenance of HSCs and B lymphopoiesis.
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