Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs.

Objectives: A profound comprehension of the molecular mechanisms underpinning the enantioselective transdermal permeation of chiral drugs is critical in the design and assessment of transdermal preparations. The primary objective of this study is to investigate the distinct skin permeation behaviors exhibited by enantiomers of non-steroidal anti-inflammatory drugs (NSAIDs) and elucidate the intricate molecular mechanism at play.

Methods: and transdermal permeation studies of chiral NSAIDs were performed using transdermal patch and solution system.