Publications by authors named "Jingtang Li"
A novel surgical method for treating fractures of the middle third of the clavicle.
J Back Musculoskelet Rehabil
May 2024
Background: The clavicle is recognized as the bone most vulnerable to fractures. Moreover, approximately 80% of fractures occur in the middle third of the clavicle. Conservative treatment is associated with a higher rate of nonunion, while surgical treatment of fracture via internal fixation may have a variety of postoperative complications.
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- This study addresses issues with dense hydroxyapatite (HAP) structures, like large grain size and low porosity, which negatively impact their use in bone integration.
- The researchers introduced hollow hydroxyapatite (hHAP) microspheres that have properties such as weak crystallization and increased surface area, which can enhance protein loading and osteoblast attachment.
- Additionally, experiments show that hHAP combined with chitosan (CS) scaffolds effectively supports bone remodeling and promotes healing by influencing calcium ion recruitment and inflammatory responses in stem cells.
Article Synopsis
- The immune microenvironment is crucial for bone formation (osteoanagenesis) and can be influenced by biomaterials that trigger specific local immune responses.
- Advancements in 3D-printing, especially using digital light projection, allow for the creation of precise biomaterial scaffolds with controlled pore sizes, which affects their osteogenic efficacy.
- In our study, hydroxyapatite scaffolds with a pore size of 600 μm improved macrophage M2 polarization and led to better inflammatory responses, vascular growth, and new bone development when implanted in animals, indicating promising applications for treating large bone defects.
Article Synopsis
- A study was conducted to explore the potential causal link between basal metabolic rate (BMR) and osteoarthritis (OA), as previous research showed inconsistent findings.
- Using genetic data, researchers assessed the relationship by examining specific single-nucleotide polymorphisms (SNPs) associated with BMR and OA.
- Results indicated a potential causal relationship, suggesting that managing BMR may help lower the risk of developing OA, particularly in the knee and hip joints.
Article Synopsis
- * This research focused on the impact of exosomes from osteoblasts (bone cells) on osteosarcoma, finding that these exosomes can inhibit cancer cell growth and encourage mineralization (bone formation).
- * The study revealed that osteoblast-derived exosomes work through the URG4/Wnt signaling pathway by enhancing certain protein expressions and inhibiting others, offering insight into potential new treatments for osteosarcoma.
Background: Osteosarcoma (OS) is a highly malignant primary bone tumor. Family of homology 60A (FAM60A) reportedly contributes to the malignant growth of some tumors.
Methods: Herein we investigated the mRNA expression level of FAM60A by combining OS and non-cancer samples from public databases.
Article Synopsis
- Bone tissue engineering aims to treat bone defects but faces challenges in creating materials that effectively recruit bone marrow mesenchymal stem cells (BMSCs) for regeneration.
- Hollow hydroxyapatite microspheres (HHMs) alone have limited ability to recruit BMSCs, so this study developed biomimetic scaffolds (HHM/chitosan and rhCXCL13-HHM/CS) that enhance bone regeneration.
- The rhCXCL13-HHM/CS scaffold successfully recruited BMSCs and promoted bone growth through the PI3K-AKT pathway, showing significant improvement in bone healing in a rabbit model over 12 weeks.
Study on the influence of scaffold morphology and structure on osteogenic performance.
Front Bioeng Biotechnol
March 2023
Article Synopsis
- * Current treatments often use cytokines for promoting fracture healing, but they can trigger immune responses and are costly, resulting in less effective clinical outcomes.
- * New research is focusing on tissue-induced biomaterials that promote bone regeneration through optimized scaffold structures, potentially improving tissue-engineered bones without the need for expensive cytokine additions.
Nowadays, ionic liquids (ILs) functionalized cyclodextrins (CDs) have drawn increasing attention in chiral separation. Herein, a novel β-CD derivative functionalized by L-histidinium IL, mono-6-deoxy-6-L-histidinium-β-cyclodextrin chloride (L-HMCDCl), was synthesized for the first time and utilized for enantioseparation of nefopam and chlorphenamine in capillary electrophoresis. The L-HMCDCl exhibited superior enantioselectivity compared with native β-CD.
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- A 22-year-old man suffered a comminuted patellar fracture after a traffic accident, which made it difficult to repair due to the complexity of the fracture.
- The treatment involved using multiple 3D-printed guide plates to assist in the reduction and fixation of the fracture.
- Over a 2-year follow-up, the patient experienced good recovery without significant limitations in knee function, highlighting the effectiveness of this innovative technique in surgical treatment.
Article Synopsis
- Circular RNAs (circRNAs) like circ_0000285 play a significant role in the progression of diseases, including osteosarcoma (OS), but their functions are not completely understood.
- Researchers found that circ_0000285 expression was higher in OS tissues and that knocking it down can reduce OS growth through various assays.
- The study revealed that circ_0000285 influences OS cell behavior by interacting with miR-409-3p and the protein IGFBP3, suggesting that targeting circ_0000285 could be a therapeutic strategy for OS.
Article Synopsis
- Autogenous and allogenic bone transplantation are common methods for treating bone issues, but they have limitations that affect their widespread use in medicine.
- This study tests PLGA microspheres carrying pOsterix/PEI nanoparticles to see if they can effectively repair bone defects and investigates how they work.
- Results show that PLGA@pOsx/PEI is safe, boosts important proteins for bone formation, and promotes bone healing in models, suggesting it could be a useful material for clinical bone repair.
Article Synopsis
- - The study explores the role of the BMP-2-TAK1-p38-Osx signaling pathway in bone repair using a composite of hollow hydroxyapatite (HA) microspheres and chitosan (CS).
- - Researchers tested the biological activity of rhBMP-2, conducted osteoblast differentiation tests, and assessed gene expression involved in bone formation.
- - Results indicate that the BMP-2-TAK1-p38-Osx pathway is crucial for bone repair, with significant differences observed in groups treated with TAK1 and p38 inhibitors, highlighting the effectiveness of the composite material in promoting bone growth.
Article Synopsis
- The study investigated how a composite made of hollow hydroxyapatite microspheres and chitosan can deliver recombinant proteins rhBMP-2 and rhCXCL13 for bone repair.
- Findings showed that rhBMP-2 enhances the proliferation and differentiation of bone marrow stem cells, while rhCXCL13 promotes their migration, leading to improved bone healing.
- The research suggests that this composite could be a promising method for bone regeneration by effectively delivering these proteins to enhance the body's repair mechanisms.
Article Synopsis
- - This study evaluated the effects of a hydroxyapatite bone repair scaffold coated with bone morphogenetic protein-2 on murine calvarial defect models, reviewing the quality of these studies based on specific reporting guidelines.
- - Out of 12 eligible studies, most had average quality scores, with key deficiencies in reporting aspects like housing, allocation, and generalizability.
- - The use of bone morphogenetic protein-2 significantly improved bone regeneration and blood vessel formation in these models, but the results indicated a lack of uniformity across the studies, emphasizing the need for adherence to reporting guidelines for better research integrity.
In this paper, a chiral selector, N-(4-H-1, 2, 4-triazolium)-lactobionamides (LA-ATM), was synthesized and applied for enantioseparation in capillary electrophoresis (CE) for the first time. Compared with lactobionic acid (LA) separation system, enhanced enantioseparation of five tested drugs was achieved in this modification system. In order to achieve good chiral separation, several parameters such as chiral selector concentration, buffer pH, applied voltage as well as the type and proportion of organic modifier were systematically investigated.
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- - This systematic review focuses on summarizing clinical studies concerning scaffolds used in repairing bony defects.
- - A thorough search on PubMed yielded 373 articles, but only 20 met the criteria for inclusion, covering both biological (like collagen) and synthetic scaffolds (such as HAp and TCP) in their analysis.
- - While the review found that scaffolds can effectively aid bone repair and regeneration, it highlighted the need for better guidelines and higher-quality research in this area.
Recently,ionic liquids (ILs) functionalized cyclodextrins (CDs) have attracted more and more attention in the fields of enantioseparation. In this study, a novel IL amino triazolium functionalized β-CD derivative, mono-6-deoxy-6-(4-amino-1,2,4-triazolium)-β-cyclodextrin chloride (4-ATMCDCl), was synthesized for the first time and managed to separate dansyl amino acids and naproxen by capillary electrophoresis (CE). Compared with native β-CD, the new selector exhibited good water solubility and enhanced enantioselectivity.
View Article and Find Full Text PDFDiscovering more superior performance of ionic liquids for the separation science has triggered increasing interest. In this work, two new Hydroxy acid-based chiral ionic liquids (CILs) (tertramethylammonium-d-pantothenate (TMA-d-PAN), tertramethylammonium-d-quinate (TMA-d-QUI)) were designed and first used as additives to establish the maltodextrin-based synergistic systems for enantioseparation in capillary electrophoresis (CE). Compared to traditional single maltodextrin chiral separation system, significantly improved separations of all tested drugs in the CIL/Maltodextrin synergistic systems were obtained.
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- The study focuses on using hollow hydroxyapatite microspheres as a synthetic substitute for bone grafts to aid in bone regeneration, particularly in large defects.
- These microspheres function as an osteoconductive matrix and deliver bone morphogenetic protein 2 (BMP2), which promotes bone growth, showing effective release in a lab setting.
- Results demonstrated that BMP2-loaded microspheres significantly improved bone healing in rabbit models compared to other methods, indicating their potential as a viable alternative in bone regeneration therapies.