The Influence of Spray Cooling Parameters on Workpiece Residual Stress of Turning GH4169.

To effectively reduce residual stresses in GH4169 workpieces, thus enhancing fatigue strength and operational lifespan, this study investigates the influence of spray cooling parameters on surface residual stresses during GH4169 turning in spray cooling conditions, utilizing both simulation and experimental approaches. A simulation model of residual stresses was established using finite element analysis when GH4169 was cut in spray cooling. The effects of spray pressure and flow rate on residual tensile stresses were analyzed.

miR-200a-3p promotes the malignancy of endometrial carcinoma through negative regulation of epithelial-mesenchymal transition.

Background: miR-200a-3p is involved in the progression of malignant behavior in various tumors, and its mechanism of action in endometrial cancer is speculated to be related to epithelial-mesenchymal transition (EMT). Therefore, this study explored the metastatic mechanism of miR-200a-3p and EMT in endometrial cancer, with the aim of identifying potential therapeutic targets.

Methods: qRT-PCR was used to analyze miR-200a-3p expression in HEC-1B and Ishikawa cell lines.