hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.

Although the composition and assembly of stress granules (SGs) are well understood, the molecular mechanisms underlying SG disassembly remain unclear. Here, we identify that heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) is associated with SGs and that its absence specifically enhances the disassembly of arsenite-induced SGs depending on the ubiquitination-proteasome system but not the autophagy pathway. hnRNPA2B1 interacts with many core SG proteins, including G3BP1, G3BP2, USP10, and Caprin-1; USP10 can deubiquitinate G3BP1; and hnRNPA2B1 depletion attenuates the G3BP1-USP10/Caprin-1 interaction but elevates the G3BP1 ubiquitination level under arsenite treatment.

Rack1 regulates pro-inflammatory cytokines by NF-κB in diabetic nephropathy.

Diabetic nephropathy (DN) is one of the chronic microvascular diseases of diabetes. Studies revealed that inflammation is involved in the development of DN. However, its mechanisms are not fully clear.

A Traceable Blockchain-Based Vaccination Record Storage and Sharing System.

Blockchain technology is essentially a decentralized database maintained by relevant parties and has been widely used in various scenarios such as logistics and finance. In terms of applications in the medical field, it is becoming more and more important because the patient's symptoms may be related to a certain vaccine. Whether the patient has been vaccinated with this vaccine will lead to different diagnostic results by the doctor.