Publications by authors named "Jingru Sui"

Article Synopsis
  • Splicing dysregulation due to spliceosomal mutations is linked to disease progression and treatment resistance primarily in blood cancers, while solid tumors show widespread splicing disorders that may promote tumor development.
  • A new computational tool called SMNPLS was created to analyze splicing dysregulation patterns in various solid tumors by examining the relationship between splicing factors and alternative splicing events.
  • The study identifies six distinct splicing dysregulation patterns affecting 40% of solid tumors and reveals similarities in dysregulation across certain cancer types, while highlighting unique patterns in brain tumors and discovering potential oncogenic splicing relationships.
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Dysfunction of intestinal epithelial Cl currents and channels have previously been reported in inflammatory intestinal diseases. However, the expression and function of the newly identified Ca-activated Cl channel transmembrane member 16A (TMEM16A) in the intestinal epithelium is unclear. In this study, we investigated the effects of TMEM16A on intestinal epithelial barrier function in vitro.

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Intestinal epithelial barrier dysfunction is a key pathology of colitis. Autophagy of epithelial cells maintains homeostasis of the intestinal barrier by inhibiting apoptosis and stimulating degradation of the tight junction protein claudin-2. This study investigated the effects and mechanism of activity of sinensetin, a polymethylated flavonoid isolated from tangerine peel and citrus, on intestinal barrier dysfunction in colitis.

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The saponins are natural surface-active glycosides which are the principal components of many popular herbal medicinal plants such as ginseng, astragalus, and bupleurum. Recent studies have suggested that saponins can exert strong anti-inflammatory effects and induce immune homeostasis in many diseases. Intestinal-inflammation-related digestive diseases include inflammatory bowel disease (IBD), irritable bowel syndrome, intestinal ischemia-reperfusion injury, necrotizing enterocolitis and radiation proctitis, as well as intestinal inflammation caused by nonsteroidal anti-inflammatory drugs.

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