Unlocking the dual role of LSD1 in tumor immunity: innate and adaptive pathways.

The roles of innate and adaptive immunity are crucial in both the development of cancer and its response to treatment. Numerous studies have demonstrated that histone lysine-specific demethylase 1 (LSD1) is overexpressed in various cancers. Elevated levels of LSD1 intricately modulate immune checkpoints, the function of immune cells, and the expression of immunomodulators, impacting both innate and adaptive immunity.

Decoding CLU (Clusterin): Conquering cancer treatment resistance and immunological barriers.

One major obstacle in the treatment of cancer is the presence of proteins resistant to cancer therapy, which can impede the effectiveness of traditional approaches such as radiation and chemotherapy. This resistance can lead to disease progression and cause treatment failure. Extensive research is currently focused on studying these proteins to create tailored treatments that can circumvent resistance mechanisms.

Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer.

Histone lysine-specific demethylase 1 (LSD1) expression has been evaluated in multiple tumors, including gastric cancer (GC). However, the mechanisms underlying LSD1 dysregulation in GC remain largely unclear. In this study, neural precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) was identified to be conjugated to LSD1 at K63 by ubiquitin-conjugating enzyme E2 M (UBE2M), and this neddylated LSD1 could promote LSD1 ubiquitination and degradation, leading to a decrease of GC cell stemness and chemoresistance.

Generation, secretion and degradation of cancer immunotherapy target PD-L1.

Cancer immunotherapy is a rapidly developing and effective method for the treatment of a variety of malignancies in recent years. As a significant immune checkpoint, programmed cell death 1 ligand 1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) play the most significant role in cancer immune escape and cancer immunotherapy. Though PD-L1 have become an important target for drug development and there have been various approved drugs and clinic trials targeting it, and various clinical response rate and adverse reactions prevent many patients from benefiting from it.

Detailed resume of RNA mA demethylases.

6-Methyladenosine (mA) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, mA modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two mA demethylases have been reported, fat mass and obesity-associated protein (FTO) and alkylation protein AlkB homolog 5 (ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability.

LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer.

Background: Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may be associated with the proliferation and metastasis of GC. It has been reported that LSD1 repressed tumor immunity through programmed cell death 1 ligand 1 (PD-L1) in melanoma and breast cancer. The role of LSD1 in the immune microenvironment of GC is unknown.

Identification of the upstream regulators of KDM5B in gastric cancer.

Aims: Lysine-specific demethylase 5B (KDM5B) is an epigenetic regulator of chromatin that catalyzes the demethylation of histone 3 lysine 4. It is overexpressed in multiple cancer types and acts as a therapeutic target in cancer therapy. Nevertheless, its upstream regulatory pathway is not completely understood, prompting the search for the underlying biological factors driving KDM5B overexpression.

Study on the spatial interaction between carbon emission intensity and shadow economy in China.

Both high carbon emission intensity (CEI) and large scale of shadow economy in China are the undesirable products of economic development with too fast growth rate. For the rapid and healthy development of the economy in China, the research on the relationship between the two should attract more attention, while the relevant literatures are very few at present. According to the panel data of 30 provinces in China from 2004 to 2016, this paper firstly examines the spatial correlation between CEI and the scale of shadow economic.

Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness.

Several studies have examined the functions of nucleic acids in small extracellular vesicles (sEVs). However, much less is known about the protein cargos of sEVs and their functions in recipient cells. This study demonstrates the presence of lysine-specific demethylase 1 (LSD1), which is the first identified histone demethylase, in the culture medium of gastric cancer cells.

Study on the long-term impact of economic globalization and population aging on CO emissions in OECD countries.

Both economic globalization and population aging have given rise to changes in environmental quality, but the research that integrates these two crucial factors into the same environment policy framework is still a blank. Therefore, using panel data of the Organization for Economic Cooperation and Development (OECD) over the period 1971-2016, this study examines the long-term impact of economic globalization and population aging on CO emissions. First, second-generation panel regression approaches are employed to verify the panel data, including unit root tests, cointegration tests and causality tests.

Convergence analysis of regional marginal abatement cost of carbon dioxide in China based on spatial panel data models.

China has announced to launch a national emission trading system (ETS). The heterogeneity of marginal abatement cost (MAC) is prerequisite for trading, and the knowledge about the evolutionary characteristics of MAC is particularly necessary. However, the β convergence theory has been proved to be suitable yet rarely applied to the study of MAC of CO.

The effect of indirect household energy consumption on PM 2.5 emission in China: An analysis based on CLA method.

PM 2.5 emissions caused by household activities are considered to be important drivers of haze formation, and indirect activities closely related to industrial structure account for a large proportion of them. This article quantifies the indirect effects on energy usage and PM 2.

Interaction between shadow economy and pollution: empirical analysis based on panel data of northeast China.

Side issues of economy development break out in China during recent decades, like environmental pollution or the widely ignored one, shadow economy. Using annual data for the three provinces at northeast China over the period 2000 to 2016, this paper examines the size of the shadow economy by MIMIC model first and then adopts the dynamic panel analysis to study the direct relationship between the shadow economy and pollution level. The major innovation point of this paper is the pioneering study of the impact from the pollution level on the size of shadow economy.

Do driving restrictions improve air quality: Take Beijing-Tianjin for example?

To manage air quality, Tianjin introduced driving restriction (DR) in 2014 and new driving restriction (NDR) in 2018. Ever since February 22th, 2018, private cars that belong to Beijing have been treated equally as local cars of Tianjin. However, existing studies rarely compare the effects of driving restrictions in different cities.

USP7: Novel Drug Target in Cancer Therapy.

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 requires the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site to a catalytically competent state by the C-terminal peptide. Until now, numerous proteins have been identified as substrates of USP7, which play a key role in cell cycle, DNA repair, chromatin remodeling, and epigenetic regulation.

Sanggenon O induced apoptosis of A549 cells is counterbalanced by protective autophagy.

Sanggenon O (SO) is a Diels-Alder type adduct extracted fromMorus alba, which has been used for its anti-inflammatory action in the Oriental medicine. However, whether it has regulatory effect on human cancer cell proliferation and what the underlying mechanism remains unknown. Here, we found that SO could significantly inhibit the growth and proliferation of A549 cells and induce its pro-apoptotic action through a caspase-dependent pathway.

Lysine demethylase 5B (KDM5B): A potential anti-cancer drug target.

Lysine demethylase 5B (KDM5B) is a histone demethylase identified in 2007, which is responsible for erasing H3K4me2/3 activation marker. It participates in multiple repressive transcriptional complexes around target gene promoters and performs wide regulatory effects on chromatin structure. Until now, there is growing evidence for the oncogenic function of KDM5B.