Global Navigation Satellite Systems (GNSS) offer comprehensive position, navigation, and timing (PNT) estimates worldwide. Given the growing demand for reliable location awareness in both indoor and outdoor contexts, the advent of fifth-generation mobile communication technology (5G) has enabled expansive coverage and precise positioning services. However, the power received by the signal of interest (SOI) at terminals is notably low.
View Article and Find Full Text PDFPolyunsaturated fatty acids (PUFAs), as important components of lipids, play indispensable roles in the development of all organisms. ∆12 fatty acid desaturase () is a speed-determining step in the biosynthesis of PUFAs. Here, we report the characterization of in which is the prevalent agent of Fusarium head blight, a destructive plant disease worldwide.
View Article and Find Full Text PDFBackground: Maize stalk rot (MSR) caused by Fusarium graminearum is the primary factor contributing to the reduction in maize yield and quality. However, this soil-borne disease presents a significant challenge for sustainable control through field management and chemical agents. The screening of novel biocontrol agents can aid in developing innovative and successful strategies for MSR control.
View Article and Find Full Text PDFBiomed Pharmacother
December 2023
The Polycomb Repressor Complex (PRC) plays a pivotal role in gene regulation during development and disease, with dysregulation contributing significantly to various human cancers. The intricate interplay between PRC and cellular signaling pathways sheds light on cancer complexity. PRC presents promising therapeutic opportunities, with inhibitors undergoing rigorous evaluation in preclinical and clinical studies.
View Article and Find Full Text PDFWe propose a communication-navigation integrated signal (CPIS), which is superimposed on the communication signal with power that does not affect the communication service, and realizes high-precision indoor positioning in a mobile communication network. Due to the occlusion of indoor obstacles and the power limitation of the positioning signal, existing carrier loop algorithms have large tracking errors in weak signal environments, which limits the positioning performance of the receiver in a complex environment. The carrier loop based on Kalman filtering (KF) has a good performance in respect of weak signals.
View Article and Find Full Text PDFThyroid-stimulating hormone (TSH) plays a crucial physiological and pathological role in humans, and a timely and sensitive detection of TSH is critical for early diagnosis and prevention of thyroid-related diseases. Herein, we developed a simple wash-free biological aptasensor based on luminescence resonance energy transfer (LRET) between NaYF:Yb,Er upconversion nanoparticles (UCNPs) and tetramethylrhodamine (TAMRA) for the detection of TSH with high sensitivity. In this LRET system, UCNPs as donors and TAMRA as receptors were modified with nucleic acid aptamers Apt-1 and Apt-2, respectively.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2022
Purpose: To explore the feasibility and repeatability of a novel glasses-free display combined with random-dot stimulus and eye-tracking technology for screening stereopsis in adults.
Methods: A total of 74 patients aged 18-44 years were recruited in this study (male: female, 32:42), including 33 patients with high myopia [≤ -6.0 diopters (D)] and 41 patients with moderate-to-low myopia (>-6.
Epigenetic modifications alter the gene activity and function by causing change in the chromosomal architecture through DNA methylation/demethylation, or histone modifications without causing any change in DNA sequence. In plants, DNA cytosine methylation (5mC) is vital for various pathways such as, gene regulation, transposon suppression, DNA repair, replication, transcription, and recombination. Thanks to recent advances in high throughput sequencing (HTS) technologies for epigenomic "Big Data" generation, accumulated studies have revealed the occurrence of another novel DNA methylation mark, N6-methyladenosine (6mA), which is highly present on gene bodies mainly activates gene expression in model plants such as eudicot Arabidopsis () and monocot rice ().
View Article and Find Full Text PDFLocation information is one of the basic elements of the Internet of Things (IoT), which is also an important research direction in the application of wireless sensor networks (WSNs). Aiming at addressing the TOA positioning problem in the low anchor node density deployment environment, the traditional cooperative localization method will reduce the positioning accuracy due to excessive redundant information. In this regard, this paper proposes a location source optimization algorithm based on fuzzy comprehensive evaluation.
View Article and Find Full Text PDFPhospholipase A (PLA) may be a vital biomarker for the prediction and diagnosis of some diseases. Consequently, it is of great significance to quantitatively detect PLA in biologic samples. Herein, on the basis of the principle of luminescence resonance energy transfer (LRET) between upconversion nanoparticles (UCNPs) and SYBR Green I (SG), we proposed a technology for the highly sensitive detection of PLA amount.
View Article and Find Full Text PDFInsig-2 is an ER membrane protein negatively controlling lipid biosynthesis. Here, we find that Insig-2 is increased in the tissues, including liver, but unaltered in the muscle of gp78-deficient mice. In hepatocytes and undifferentiated C2C12 myoblasts, Insig-2 is ubiquitylated on Cys215 by gp78 and degraded.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
November 2019
Recently, molybdenum disulfide functionalized with poly-ethylene glycol (PEGylated MoS) has been widely used as a new drug delivery vehicle in biomedical field. However, the weak antibacterial activity of PEGylated MoS limits its application as an antibacterial agent. In this work, a novel silkworm-like conjugate of nisin loaded PEGylated MoS (nisin@PEGylated MoS) was developed for antibacterial application.
View Article and Find Full Text PDFThe effect of single-layer graphene sheets (Gr) on the corrosion protection of zinc-rich epoxy primers (ZRPs) was investigated. Scanning electron microscopy (SEM) with an energy dispersive spectrometer (EDS) were used to characterize morphology and composition of the coatings after immersion for 25 days. The cross-sectional SEM images and X-ray photoelectron spectroscopy (XPS) confirmed that the addition of single-layer graphene facilitated assembling of zinc oxides on the interface between the coating and the steel.
View Article and Find Full Text PDFN-Methyladenine (6mA) DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes, including the dicot model Arabidopsis thaliana. However, the conservation and divergence of 6mA distribution patterns and functions in plants remain elusive. Here we report high-quality 6mA methylomes at single-nucleotide resolution in rice based on substantially improved genome sequences of two rice cultivars, Nipponbare (Nip; Japonica) and 93-11 (Indica).
View Article and Find Full Text PDFIn this work, p-hydroxybenzenesulfonic acid-formaldehyde resin acid catalyst (MSPFR), was synthesized by a hydrothermal method, and employed for the furfural production from raw corn stover. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), N adsorption-desorption, elemental analysis (EA), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FT-IR) were used to characterize the MSPFR. The effects of reaction time, temperature, solvents and corn stover loading were investigated.
View Article and Find Full Text PDFA montmorillonite@chitosan-poly (ethylene oxide) nanofibrous membrane (MMT@CPF) enhancing poly (vinyl alcohol-co-ethylene) (EVOH-MMT@CPF) composite film was developed by using a space-filling embedding method. The structure of EVOH-MMT@CPF was characterized, and the thermal stability, mechanical and barrier properties of the films were investigated. The CPF was fabricated via electrospinning technique and the self-assembly of MMT nano-platelets on CPF was achieved by the driving of electrostatic interactions between MMT nano-platelet and CPF.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
February 2016
Objective: To develop a novel colorimetric method for detecting the tumor biomarker vascular endothelial growth factor (VEGF) based on aptamer and magnetic beads.
Methods: The capture aptamer was hybridized to urease functionalized single-stranded DNA (ssDNA) and immobilize on the surface of magnetic beads by specific biotin-avidin binding. In the presence of VEGF, aptamers bound to VEGF to form a specific stem-loop structure to release the urease functionalized ssDNA.
Objective: To evaluate the effects of short-term VDT usage on visual functions.
Methods: Visual function of the video display terminal (VDT) operators before and after 1 hour VDT usage were assessed. These included refraction, amplitude of accommodation, near point of convergence, AC/A, phorias, fusional convergence and divergence, tear film break time (BUT) and aberrations.