Publications by authors named "Jingran Wang"

Acetylcholinesterase (AChE) plays a vital role in various neurological diseases including brain disorders, neurotransmission alterations, and cancer. Developing effective methods to image AChE in biological samples is essential for understanding its mechanisms in biosystems. Here, we introduce a novel fluorescent probe CNA, that enables detection of AChE at 520 nm with rapid response time of 60 s and a detection limit of 0.

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In this study, we introduced a novel fluorescent probe RNP, which demonstrated outstanding sensitivity and specificity for phosgene detection. Upon phosgene exposure, the probe exhibited rapid fluorescence turn-on within a short re-sponse time (6 s). RNP was also effective in both cellular and murine experiments, where fluorescence enhancement was observed in the respiratory tract of mice.

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A visible-light-driven radical C-H methylation of -heteroarenes that is efficient and additive- and catalyst-free and employs readily available ,-dimethylethanolamine as the methyl source has been developed. The transformation offers the benefits of broad substrate scope, mild reaction conditions, and operational simplicity. A photoactive electron donor-acceptor (EDA) complex between -heteroarenes and ,-dimethylethanolamine is essential for this transformation, as revealed by mechanistic investigations.

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Article Synopsis
  • Sepsis is a serious condition with high rates of incidence and death, and it's linked to changes in gut microbiota, sparking interest in research on this interaction.
  • The review discusses the challenges in proving a direct causal relationship between sepsis and gut microbiota imbalances due to the complexity of critical illness and various treatments.
  • It proposes new targeted therapies based on microbiome research and highlights the need for better bacterial selection and timing in treatment, while emphasizing ongoing studies that may lead to effective probiotics for restoring gut health in sepsis patients.
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  • * BRAF V600E mutation AF is associated with higher risks of thyroid capsule penetration, recurrence, and is often found with other mutations that worsen prognosis, while TERT mutations are commonly linked to other mutations but do not show a clear connection to tumor invasiveness.
  • * The research indicates that BRAF V600E AF above 28.2% can predict recurrence in PTC patients with a sensitivity of 60% and specificity of 80%, suggesting it could be
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The environmental behavior of and risks associated with nanoplastics (NPs) have attracted considerable attention. However, compared to pristine NPs, environmental factors such as ultraviolet (UV) irradiation that lead to changes in the toxicity of NPs have rarely been studied. We evaluated the changes in morphology and physicochemical properties of polystyrene (PS) NPs before and after UV irradiation, and compared their hepatotoxicity in mice.

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With the detection of nano-plastics (NPs) in daily essentials and drinking water, the potential harm of NPs to human health has become the focus of global attention. Studies have shown that long term exposure to NPs can lead to disorders of glucose and lipid metabolism in organisms, while the effects of short term exposure are rarely reported. Moreover, environmental factors cause the aging of NPs, and it is unclear whether this has an effect on their toxicity.

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Aim: To study the microecological characteristics of the airway and similarities and differences between healthy people and patients with the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in Inner Mongolia, and analyze the correlation between the characteristics of the airway microecological structure and clinical indicators of AECOPD patients.

Methods: Sputum samples from 36 healthy volunteers and 34 patients with AECOPD were detected by 16S rDNA high-throughput sequencing, and the airway microecological characteristics of healthy people and AECOPD patients were revealed by an alpha diversity analysis, beta diversity analysis, and LefSe difference analysis.

Results: There were differences in the airway microecological structure between healthy people and AECOPD patients in Inner Mongolia.

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Autophagy is an essential degradation pathway that assists eukaryote survival under multiple stress conditions. Autophagosomes engulfing cargoes accomplish degradation only when they have matured through fusing with lysosomes or vacuoles. However, the molecular machinery mediating autophagosome maturation in plants remains unknown.

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Autophagy is an evolutionarily conserved catabolic process in eukaryotic cells, by which the superfluous or damaged cytoplasmic components can be delivered into vacuoles or lysosomes for degradation and recycling. Two decades of autophagy research in plants uncovers the important roles of autophagy during diverse biological processes, including development, metabolism, and various stress responses. Additionally, molecular machineries contributing to plant autophagy onset and regulation have also gradually come into people's sights.

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In this study, the contents of heavy metals and Cd and Pb isotope ratios of agricultural soil and potential source samples collected from farmland receiving sewage irrigation in Wuqing District, Tianjin, China were determined. Multiple methods were used for source analysis, including positive matrix factorization (PMF), correlation analysis, principal component analysis (PCA), and the Cd and Pb isotope ratio method. The results showed that agricultural soil was slightly contaminated by heavy metals in the research area, with relatively higher Cd and Pb accumulation levels compared to those of other heavy metals.

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In response to the serious problem of backflow in valveless piezoelectric pumps, this paper proposes a valveless piezoelectric pump with a bullhorn-shaped structure. In this paper, we analyze the flow guide by using the "tail flow space pressure comparison method" and "fluid unit dynamic analysis method," revealing the working principle of the flow guide in the valveless piezoelectric pump. The effects of the height, sharp angle, and filter angle of the bullhorn-shaped structure on the output flow were investigated separately by the experiment.

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Mammalian sperm is highly susceptible to reactive oxygen species (ROS) during the cryopreservation process. Astaxanthin (AST), a red pigment of the carotenoid family, is recognized as having a variety of beneficial biological activities and effects, including antioxidant, anticancer, anti-diabetic, and anti-inflammatory. The present study aimed to investigate whether the presence of AST protected boar sperm from ROS stress during cryopreservation.

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Objective: This study was conducted to investigate the effect of L-carnitine on the pig semen characteristics during storage.

Methods: Spermatozoa samples were examined for spermatozoa quality and then randomly divided into 5 groups: 0 (control), 12.5, 25, 50, and 100 mM L-carnitine.

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Spermatozoa are highly specialized cells, and energy metabolism plays an important role in modulating sperm viability and function. Rosiglitazone is an antidiabetic drug in the thiazolidinedione class that regulates metabolic flexibility and glucose uptake in various cell types, but its effects on boar sperm metabolism are unknown. In this study, we investigated the potential effect of rosiglitazone against time-dependent deterioration of boar spermatozoa during liquid preservation at 17°C.

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The quality of boar spermatozoa is affected by oxidative stress during preservation in vitro. It has been demonstrated that L-Glutamine (Gln) can effectively protect cells from oxidative stress-induced injury. There are, however, no reports to date evaluating the effects of Gln on boar semen liquid preservation at 17 °C.

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Altered microRNA (miRNA) expression has been reported to participate in the pathogenesis of several human diseases, and particularly cancer. The present study examined the involvement of various miRNAs in the pathophysiology of endometrial cancer (EC) and atypical endometrial hyperplasia (AEH). We performed a high-throughput analysis of the miRNAs (miRNA microarray) found in samples of endometrial tissue obtained from 45 patients; among whom, 15 patients were diagnosed with EC, 15 patients were diagnosed with AEH, and the remainder were healthy donors.

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Background: The American Heart Association/American Stroke Association proposed a metric called Life's Simple 7 (LS7) to define cardiovascular health (CVH). The presence of a large number of ideal components of CVH is associated with lower cardiovascular disease and all-cause mortality. We aimed to assess CVH using LS7 in a Chinese population undergoing primary and secondary stroke prevention.

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The Moon may be considered as the frontier base for the deep space exploration. The spectral analysis is one of the key techniques to determine the lunar surface rock and mineral compositions. But the lunar topographic relief is more remarkable than that of the Earth.

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It was reported that the intron 6, + 1 del G (GT>TT) mutation of the ARHGEF28 gene generates a shortened protein that might be related to amyotrophic lateral sclerosis (ALS). We sequenced this mutation in 25 familial ALS (FALS), 357 sporadic ALS (SALS) patients, and 442 healthy control subjects. We found just two SALS patients exhibited the mutation so that the incidence of this mutation was 0.

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An efficient phosphine-free direct C-H arylation of thiophenes at the α-position has been developed at low catalyst loading of bis(alkoxo)palladium complex (Cat.I, 0.1-0.

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