Publications by authors named "Jingran Deng"
Palladium porphyrin complexes for photodynamic cancer therapy: effect of porphyrin units and metal.
Photochem Photobiol Sci
July 2020
Article Synopsis
- Photodynamic therapy (PDT) has been studied as a treatment for malignant tissues, and this research focuses on synthesizing and evaluating porphyrin compounds attached to alkyl chains and coordinated with palladium.
- The generation of reactive oxygen species (ROS) was tested, revealing that palladium porphyrin complexes produced more ROS than free base porphyrins, with effectiveness increasing with more porphyrin units.
- The synthesized photosensitizers showed good biocompatibility in the dark and higher therapeutic activity when exposed to light, with Pd-Tripor demonstrating the lowest IC value (9.6 μM), indicating better therapeutic potential.
Correction for 'A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy' by Mengqian Yang et al., Org. Biomol.
View Article and Find Full Text PDFA new folate-conjugated platinum porphyrin complex (Por 4) was synthesized and characterized. The singlet oxygen production of the conjugates was evaluated through a 1,3-diphenylisobenzofuran method. The targeting ability and subcellular localization of Por 4 were confirmed by confocal laser scanning microscopy in HeLa cells (overexpression of FR) as well as in A549 cells (low expression of FR).
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