Publications by authors named "Jingna Gu"
Ethnopharmacological Relevance: Guilu Erxian Jiao (GLEXJ) is a renowned traditional Chinese herbal formula used to tonify the kidney. It is employed to treat psychiatric disorders, and alleviate memory impairment, cognitive dysfunction, and behavioral disorders. Modern pharmacological studies have demonstrated GLEXJ's ability to significantly inhibit the fear response in post-traumatic stress disorder (PTSD) and facilitate the extinction of fear memory.
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- The study investigates how the protein LCN-2 and the NF-κB signaling pathway relate to inflammation in a rat model of polycystic ovary syndrome with insulin resistance (PCOS-IR) and how modified Cangfu Daotan decoction (MCDD) can influence this relationship.
- Rats were fed a high-fat diet and treated with letrozole to create the PCOS-IR model, followed by a 28-day MCDD treatment with varying doses.
- Results indicated that MCDD improved body weight, ovarian function, and inflammatory responses in the rats, suggesting that it may enhance ovarian health by regulating NF-κB and insulin signaling pathways in the context of inflammation.