Validation of an Ion-Pair Reverse Phase High-Performance Liquid Chromatography Method for the Detection of Major Components and Related Substances in Diquafosol Sodium Eye Drops.

A simple, feasible, isocratic elution, and stable reversed-phase high performance liquid chromatography method was established and verified. The chromatographic conditions are as follows: EF-C18H, 4.6 × 250 mm, 5 μm column; column temperature 30 °C; for the mobile phase 27.

Ultrasensitive and Exclusive Chemiresistors with a ZIF-67-Derived Oxide Cage/Nanofiber CoO/InO Heterostructure for Acetone Detection.

Gas sensors for acetone detection have received considerable attention because acetone has a significant influence on both the environment and human health, e.g., it is flammable and toxic and may be related to blood glucose levels.

Enhanced Acetone-Sensing Properties of Pt-Decorated InO Hollow Microspheres Derived from Pt-Embedded Template.

Pt-decorated InO hollow microspheres were prepared using a template and reflux method. The size of the prepared carbon templates was adjusted from 200 nm to 1.3 μm by introducing chloroplatinic acid during the hydrothermal process.

Characteristics of Activation Rate and Damage of Ion-Implanted Phosphorous in 4H-SiC after Different Annealing by Optical Absorption.

We investigated the ellipsometer-based characterization method being used to quickly evaluate the depth of the damage layer in ion-implanted 4H-SiC. This method had the advantages of low cost, convenience, and non-destructiveness. Optical absorption of n-type 4H-SiC substrate, P ion-implanted, laser-annealed, and conventional high-temperature annealed wafers were investigated at room temperature.

Facile preparation of collagen fiber-glycerol-carboxymethyl cellulose composite film by immersing method.

Carboxymethyl cellulose (CMC) and glycerol were added by immersing neutralized collagen fiber paste into CMC/glycerol aqueous solutions with different mass ratios, forming composite films. CMC decreased the glycerol adsorption by 49.5%.

Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy.

In this study, we aimed to investigate the associations between Sirt6, macrophages and diabetic nephropathy (DN). Immunohistochemical, western blot and RT‑qPCR analyses were performed to detect the expression levels of Sirt6, the markers of podocytes and monocytes and related inflammatory factors in the tissues of rats with streptozocin‑induced DN. A series of cell experiments in isolated culture or the co‑culture of macrophages and podocytes were conducted to examine the effects of the overexpression of Sirt6 on macrophage transformation, podocyte apoptosis and associated genes, and analyses were performed using RT‑qPCR, flow cytometry and western blot analysis, where appropriate.

Exceptional crystallization diversity and solid-state conversions of Cd(II) coordination frameworks with 5-bromonicotinate directed by solvent media.

A series of nine coordination polymers {[Cd(L)(2)(solvent)(x)](solvent)(y)}(n) have been prepared from Cd(NO(3))(2) and 5-bromonicotinic acid (HL) in different solvents through a layered diffusion method. By using CH(3)OH/H(2)O at different volume ratios of 1:1 and 1:3, a one-dimensional (1D) coordination species (1a) and a three-dimensional (3D) (3,6)-connected framework (2a·g(1)) can be obtained. A similar self-assembly process in C(2)H(5)OH/H(2)O or H(2)O/1,4-dioxane gives 2a·g(2) or 2a·g(3), which are isomorphic to 2a·g(1) but with different lattice solvents.

[NDM-1-producing Klebsiella pneumoniae in mainland China].

Objective: To investigate the characteristics of New Delhi metallo-beta-lactamase-1 (NDM-1) gene of Klebsiella pneumoniae (K. pneumoniae) emerging in Hunan, and its relationship to antibiotic resistance.

Methods: The clinical strain was isolated from a sputum sample of a child with severe pnemonia and toxic myocarditis who was admitted into a general hospital of Hunan Province.

[Molecular epidemiological characteristics of clinically isolated carbapenem-resistant Acinetobacter baumannii in Changsha].

Objective: To survey antibiotic resistance of clinical isolates of Acinetobacter baumannii in Changsha and to investigate molecular epidemiological characteristics of carbapenem-resistant Acinetobacter baumannii.

Methods: A total of 205 non-duplicated, clinical isolates of Acinetabacter baumannii from 10 general hospitals in Changsha were collected from March 2010 to December 2010. The K-B disk diffusion method was applied for the drug-susceptibility test; a modified, double-disk synergy test was used to detect metallo-β-lactamase (MBL), and a modified Hodge test was used for the screening of carbapenemase.

Inducing effect of additive agents on coordination assembly of silver(I) nitrate with 3,5-bis(2-pyridyl)-4-amino-1,2,4-triazole: supramolecular isomerism and interconversion.

By using different organic acids as additive agents, hydrothermal reactions of AgNO(3) with 3,5-bis(2-pyridyl)-4-amino-1,2,4-triazole (2-bpt) lead to formation of two conformational polymorphs of [Ag(2-bpt)](NO(3)) with bimetallocyclic and 1-D helical coordination patterns. Interconversion between the two supramolecular isomers can be achieved under proper conditions, which will pass through the same intermediate state.

2,5-Bis(5-methyl-pyrazin-2-yl)-1,3,4-oxadiazole.

In the title mol-ecule, C(12)H(10)N(6)O, the dihedral angle between the two pyrazine rings [planar to within 0.009 (3) and 0.018 (3) Å] is 5.

3,4-Bis(2-pyrid-yl)-5-(3-pyrid-yl)-4H-1,2,4-triazole.

In the title mol-ecule, C(17)H(12)N(6), the 2-pyridyl rings in the 3- and 4-positions and the 3-pyridyl ring in the 5-position make dihedral angles of 29.78 (16), 67.06 (16) and 32.

Destruction and reconstruction of the robust [Cu2(OOCR)4] unit during crystal structure transformations between two coordination polymers.

This work first demonstrates that the robust [Cu(2)(OOCR)(4)] unit can be destroyed and reconstructed in the solid state, as observed in water-induced structural interconversion of two distinct coordination polymers with 5-bromonicotinate.

[Pharmacokinetic study of intraperitoneal chemotherapy with HCPT].

Objective: To study the pharmacokinetic of 10-Hydroxycamptothecin HCPT by intraperitoneal administration.

Method: Six dogs were given HCPT by intraperitoneal perfusion: HCPT 2 mg x kg(-1), dissolved in 300 mL NS. During the course of experiments, peritoneal fluids and blood were sampled using a standardized protocol.

Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema.

Hand, foot, and mouth disease and herpangina are the major clinical manifestations of enterovirus 71 (EV71) infections. Brain-stem encephalitis and pulmonary edema are severe complications that can lead to death. This study was designed to evaluate the potential therapeutic effect of milrinone, a phosphodiesterase (PDE) inhibitor, in the treatment of patients with EV71-induced pulmonary edema.