In knee osteoarthritis (KOA), different types of mesenchymal stem cells (MSCs) like BM-MSC, AD-MSC, and UC-MSC are being researched for their effectiveness in treating symptoms, but it's unclear which is best.
The study analyzed 15 studies with 585 patients using meta-analysis to evaluate outcomes like pain relief (VAS), motion range (ROM), and overall health indicators (WOMAC) until January 1, 2024.
Results showed that autologous BM-MSC provided the best improvements in pain and motion, while UC-MSC had the best outcomes for MRI results and AD-MSC were effective for quality of life assessments, although all MSC types had more adverse reactions compared to