Publications by authors named "Jinglin Qiu"
Article Synopsis
- Deinagkistrodon acutus, a pitviper found mostly in South China and Taiwan, has venom rich in metalloproteases and C-type lectin-like proteins that can cause severe bleeding.
- This study explored the differences in venom composition between specimens from Taiwan and four provinces in Mainland China using various biochemical methods, finding distinct variations in venom proteins and their expression.
- The Taiwanese D. acutus venom showed higher reactivity with a specific antivenom compared to Mainland Chinese venoms, and there was noted cross-reactivity with Crotalus horridus venom, which suggests similarities in certain venom components.
Tristetraprolin (TTP), an important immunosuppressive protein regulating mRNA decay through recognition of the AU-rich elements (AREs) within the 3'-UTRs of mRNAs, participates in the pathogenesis of liver diseases. However, whether TTP regulates mRNA stability through other mechanisms remains poorly understood. Here, we report that TTP was upregulated in acute liver failure (ALF), resulting in decreased mRNA stabilities of CCL2 and CCL5 through promotion of N6-methyladenosine (m6A) mRNA methylation.
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