Assessing the impact of community-based homestay experiences on tourist loyalty in sustainable rural tourism development.

In the context of community-based tourism, this study investigates the determinants of tourist loyalty to homestays, with a focus on sustainable rural tourism development in China. Using the stimulus-organism-response (SOR) framework, we propose a conceptual model to examine how connected experiences influence tourist emotions and, in turn, their loyalty. Data were gathered through onsite surveys of tourists, and structural equation modeling was applied to assess the relationships between key variables.

Isobutyric Acid Promotes Immune Evasion in Colorectal Cancer via Increased PD-L1 Expression.

Introduction: Isobutyric acid (IBA), a short-chain fatty acid, has been unequivocally demonstrated to exert significant influence on the progression of colorectal cancer (CRC). Nevertheless, a comprehensive understanding of its intricate regulatory mechanisms remains elusive.

Methods: Employing advanced techniques such as western blot, RT-qPCR, and flow cytometry, we systematically investigated the impact of IBA on the expression of PD-L1 in CRC cells.

The circular RNA circ_0001742 regulates colorectal carcinoma proliferation and migration via the MicroRNA-431-5p/ALG8 axis.

Background: Accumulating studies have found that circular RNAs (circRNAs) have a regulatory effect in a variety of tumors. However, to date, the relationship between specific circRNAs and colorectal cancer (CRC) remains elusive.

Methods: An RNA-sequencing method based on different metastatic potential of CRC cell lines was applied to evaluate the circRNA expression profile.

Isobutyric acid promotes colorectal cancer metastasis through activating RACK1.

Colorectal cancer (CRC) metastasis plays a crucial role in disease progression, yet the regulatory mechanisms underlying metastasis remain incompletely understood. Isobutyric acid (IBA), a short-chain fatty acid found at high levels in serum of CRC patients, has been shown to be a critical metabolite influencing CRC proliferation. However, its role in tumor metastasis remains unknown.

Numerical Simulation of Mass Transfer and Three-Dimensional Fabrication of Tissue-Engineered Cartilages Based on Chitosan/Gelatin Hybrid Hydrogel Scaffold in a Rotating Bioreactor.

Cartilage tissue engineering is believed to provide effective cartilage repair post-injuries or diseases. Biomedical materials play a key role in achieving successful culture and fabrication of cartilage. The physical properties of a chitosan/gelatin hybrid hydrogel scaffold make it an ideal cartilage biomimetic material.

Ergonomic evaluation of the operating characteristics of the 6MF-30 portable pneumatic extinguisher.

The 6MF-30 portable pneumatic extinguisher, which is one of the most widely used pieces of equipment for fighting forest fires in China, can produce great physical discomfort for the wearer. To mitigate the physical discomfort associated with the use of the 6MF-30, the operating characteristics of this machine were ergonomically evaluated. Fourteen subjects were instructed to operate the 6MF-30 portable pneumatic extinguisher using three different carrying postures (oblique strap, vertical strap and no strap) two different motions (stationary and swinging) during a simulated firefighting task.

[Application of folded soft palate plasty to obstructive sleep apnea hypopnea syndrome].

Objective: To explore the effect of the modified (Uvulopalatopharyngoplasty, UPPP) where uvula is reserved completely and the soft palate is folded in the operation.

Methods: 36 patients with the obstructive sleep apnea-hypopnea syndrome (OSAHS) (30 men, 6 women) underwent operation. The uvula and the muscles of the soft palate were reserved completely, and the soft palate was folded during the operation.