The value of NIPT combined with serum cell-free DNA, estriol, AFP, and b-HCG levels in the recognition of trisomy 21 and 18 in the second trimester.

Background: This study aimed to evaluate the clinical application value of noninvasive prenatal testing from DNA (NIPT) and serum screening for screening in detecting fetal trisomy 21 and 18.

Methods: As a retrospective analysis, we collected data from 1383 women (singleton pregnancy) who underwent serum screening and noninvasive prenatal testing from DNA (NIPT) in our department from May 2015 to September 2017 and calculated the diagnostic value of the two methods.

Dynamic analysis of a phytoplankton-fish model with the impulsive feedback control depending on the fish density and its changing rate.

This paper proposes and studies a comprehensive control model that considers fish population density and its current growth rate, providing new ideas for fishing strategies. First, we established a phytoplankton-fish model with state-impulse feedback control based on fish density and rate of change. Secondly, the complex phase sets and impulse sets of the model are divided into three cases, then the Poincaré map of the model is defined and its complex dynamic properties are deeply studied.

Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy.

Background And Aim: Rifampicin is the most common pathogenic factor in anti-tuberculosis drug-induced liver injury (AT-DILI), the mechanisms that it promotes hepatocyte damage in AT-DILI are not yet to be thoroughly elucidated. In this study, we investigated the potential molecular mechanisms for ferroptosis involving rifampicin hepatotoxicity.

Methods: Animal and cell injury models of rifampicin were constructed, and the toxicity of rifampicin was assessed by physicochemical staining and cell viability assay.

Noninvasive prenatal testing for chromosome aneuploidies and subchromosomal microdeletions/microduplications in a cohort of 8141 single pregnancies.

Background: Noninvasive prenatal testing (NIPT) for fetal aneuploidies by scanning cell-free fetal DNA in maternal plasma is rapidly becoming a first-tier aneuploidy screening test in clinical practices. With the development of whole-genome sequencing technology, small subchromosomal deletions and duplications that could not be detected by conventional karyotyping are now able to be detected with NIPT technology.

Methods: In the present study, we examined 8141 single pregnancies with NIPT to calculate the positive predictive values of each of the chromosome aneuploidies and the subchromosomal microdeletions and microduplications.

Efficacy and safety of misoprostol compared with the dinoprostone for labor induction at term: a meta-analysis.

Objective: The purpose of this study was to compare the efficacy and safety of intravaginal misoprostol and the dinoprostone vaginal insert for labor induction at term.

Method: PubMed, EMBASE, MEDLINE, CNKI, EBSCO and the Cochrane Library were searched for articles published in English language from 2000 to 2014, Using the keywords misoprostol, dinoprostone, labor induction.

Results: Eight of 436 studies (1669 women) identified met the criteria for meta-analysis.

Which is the safer method of labor induction for oligohydramnios women? Transcervical double balloon catheter or dinoprostone vaginal insert.

Objective: To compare the effectiveness and safety of two cervical ripening methods in term primiparous women with unfavorable cervices and oligohydramnios.

Methods: Women (126 cases) with oligohydramnios [amniotic fluid index (AFI) ≤5 cm] and a low Bishop Score (≤6) were assigned randomly to use double balloon catheter (mechanical method group, 67 cases) or dinoprostone 10 mg controlled-release vaginal insert (pharmacological method group, 59 cases) for induction of labor. The study's primary outcome was caesarean section rate (CSR).

[The investigations on the relationship between the birth weight of fetus and the P70 S6K as well as mechanism insulin regulate the birth weight of fetus].

Objectives: To investigate the relationship between the birth weight of fetus and the P(70)S6K from ribosome in cells of placental tissues and investigate whether insulin can affect the P(70)S6K by the PI3K/AKT/mTOR (P(70)S6K) signaling pathway in the cells of the placental tissues and more regulate the birth weight of fetus.

Methods: (1) 60 cases of mature placental tissues after uterine-incision delivery without complications in the gestational period were selected as the investigated subjects, they were divided into three groups according to their birth weights. group 1.