Publications by authors named "Jinglan Mu"

Article Synopsis
  • The study aimed to create a mouse model for postoperative delirium to better understand its mechanisms, using a method involving repeated clamping of the superior mesenteric artery.
  • Results showed that the induced ischemia/reperfusion (I/R) led to significant anxiety and cognitive decline in mice, with microglial activity in the brain closely linked to these behavioral changes.
  • Treatment with minocycline reduced harmful compounds linked to cognitive deficits and showed potential in managing the effects of elevated IL-6 levels on microglial activation post-surgery.
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Objective: To develop a clinical practice guideline to guide the treatment of low back pain by acupuncture.

Methods: An integrative approach of systematic review of literature, clinical evidence classification, expert opinion surveying, and consensus establishing via a Delphi program was utilized during the developing process. Both evidence-based practice standards and the personalized features of acupuncture were taken into considerations.

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Background: Chronic nonspecific low back pain (LBP) is very common; it is defined as pain without a recognizable etiology that lasts for more than three months. Some clinical practice guidelines suggest that acupuncture can offer an effective alternative therapy. This review is a split from an earlier Cochrane review and it focuses on chronic LBP.

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We investigated the effect of 1.4% isoflurane (ISO) on the development of inflammation and apoptosis caused by zymosan (ZY) in mice. We found that ZY-challenged mice exhibited significant body weight loss, markedly high mortality, and significant lung injury characterized by the deterioration of histopathology, histologic scores, and wet-to-dry ratio after ISO treatment.

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Background: The 100% oxygen inhalation has been demonstrated to have a protective effect on mice with zymosan-induced generalized inflammation. However, the underlying mechanism is largely unknown. The present study was designed to explore the role of the cholinergic anti-inflammatory pathway in this animal model.

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Background: Hydrogen gas, an antioxidant agent, was found to protect against cerebral and myocardial ischemia-reperfusion (I/R) injury. In the present study, we investigated the effect of hydrogen-rich saline (HRS) on the I/R-induced lung injury.

Methods: Left lung of male New Zealand White rabbits rendered normothermic ischemia for 60 min and reperfused for up to 240 min.

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Multiple organ dysfunction syndrome (MODS) is one of the leading causes of death in the intensive care unit. Organ failure especially lung injury is highly associated with the mortality for MODS patients. Volatile anesthetic isoflurane (ISO) is one of the most widely used anesthetic agents, and ISO anesthesia has been reported to improve the survival rate and organ function in sepsis/MODS models.

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