Metronidazole-modified Au@BSA nanocomposites for dual sensitization of radiotherapy in solid tumors.

The hypoxic microenvironment of solid tumors can lead to reduced therapeutic DNA damage to the tumor cells, thus diminishing tumor sensitivity to radiotherapy. Although hypoxic radiosensitizers can improve radiotherapy efficacy by enhancing the role of oxygen, their effects are limited by the uneven distribution of oxygen within solid tumor tissues. In this study, a novel radiosensitizer leveraging gold complexes and metronidazole (MN) was synthesized to improve radiotherapeutic efficacy.

Sulfonic Acid-Functionalized Tetraphenylethylene-Amplified Electrochemiluminescence by Regulating π-π Interaction.

The electrochemiluminescence (ECL) effectiveness of the tris(bipyridine) ruthenium(II) (Ru(bpy)) system is hampered by aggregation-caused quenching (ACQ) in optoelectronic systems as a result of π-π accumulation of the aromatic ring structure. In this work, a negatively charged tetraphenylvinyl molecule (TPE-2SONa, TPE-4SONa) was synthesized to modify the electrode interface, and the π-π accumulation between Ru(bpy) molecules was transformed into the π-π interaction between Ru(bpy) and TPE molecules. Interestingly, the ECL signal intensity of the Ru(bpy)-tripropylamine (TPA) system in the presence of TPE-2SONa was increased by about 15 times due to the π-π action and electrostatic action.