Publications by authors named "Jingjing Sun"

This study investigates the feasibility and effectiveness of integrating Attribute-Based Encryption (ABE) into smart healthcare networks, with a particular focus on its role in enhancing anti-corruption mechanisms. The study provides a comprehensive analysis of current vulnerabilities in these networks, identifying potential data security risks. An anti-corruption mechanism is designed to ensure data integrity and reliability.

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Introduction: Smart cities, artificial intelligence (AI) in healthcare, and low-carbon building materials are pivotal to public health, environmental sustainability, and green efficiency. Despite their critical importance, understanding public perceptions and attitudes toward these domains remains underexplored. Additionally, the effective use of advanced technologies like convolutional neural networks (CNN) in predicting and promoting low-carbon solutions in construction is gaining attention.

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With the accelerated urbanization and economic development in Northwest China, the efficiency of urban wastewater treatment and the importance of water quality management have become increasingly significant. This work aims to explore urban wastewater treatment and carbon reduction mechanisms in Northwest China to alleviate water resource pressure. By utilizing online monitoring data from pilot systems, it conducts an in-depth analysis of the impacts of different wastewater treatment processes on water quality parameters.

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Queuosine (Q) is a modification of the wobble base in tRNAs that decode NA(C/U) codons. It is ubiquitous in bacteria, including many pathogens. Streptococcus mutans is an early colonizer of dental plaque biofilm and a key player in dental caries.

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Background: Chronic inflammatory pain is a pervasive condition, and electroacupuncture (EA) is an effective treatment, but its mechanisms are not fully understood. AMP-activated protein kinase (AMPK), a key energy sensor, is involved in pain relief and EA's effects. EA may work by increasing endocannabinoids, upregulating CB2 receptors (CB2R), and stimulating β-endorphin (β-END).

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Tissue engineering presents promising avenues for addressing issues related to tissue defects and regenerative medicine. However, the translational efficacy of tissue engineering in clinical settings remains limited, primarily due to the inadequate survival rates of implanted tissue scaffolds. This is attributed to the grafts' inability to adequately supply oxygen and their dependence on the diffusion of oxygen from surrounding tissues for tissue regeneration.

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Background: Langerhans cell histiocytosis (LCH) is the most prevalent histiocytic disorder in pediatric populations, with a highly heterogeneous clinical presentation. Currently, the correlation between clinical phenotypes and molecular alterations in childhood LCH, besides the BRAF mutation, has not been sufficiently studied.

Methods: This study presented data on 33 pediatric LCH patients treated at our center who exhibited various molecular alterations other than the BRAF mutation.

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Background: To explore the efficacy of theta burst stimulation (TBS) on the negative symptoms in patients with chronic schizophrenia, and to investigate the alterations of local brain activity using functional near-infrared spectroscopy (fNIRS).

Methods: 100 patients with chronic schizophrenia were enrolled and divided into the real group (50 subjects) and sham group (50 subjects). The real group was given real stimulation of TBS for 4 weeks, and the sham group was sham-stimulated with the same site.

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Incompatible plasmids play a crucial role in the horizontal transfer of antibiotic resistance in bacteria, particularly in Gram-negative bacteria, and have thus attracted considerable attention in the field of microbiological research. In the 1970s, these plasmids, housing an array of resistance genes and genetic elements, were predominantly discovered. They exhibit a broad presence in diverse host bacteria, showcasing diversity in geographic distribution and the spectrum of antibiotic resistance genes.

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NaVMn(PO) (NVMP) is a prospective cathode for sodium-ion batteries (SIBs) due to its low cost and extraordinary structural stability. However, poor conductivity restricts the electrochemical performance of NVMP, which limits its development and application. Herein, carbon-encapsulated NVMP porous nanorods are prepared via a convenient electrospinning method.

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The management of neurological disorders is profoundly complicated by spinal cord injury (SCI), which leads to the impairment of motor and sensory functions. A major challenge in the treatment of SCI is the formation of a dysfunctional pathological microenvironment characterized by an excessive inflammatory response, deposition of inhibitory molecules, glial scarring, and vascular dysfunction. A thorough understanding of the pathological and physiological changes following SCI is essential to elucidate the mechanisms underlying functional recovery and to develop effective therapeutic interventions.

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Article Synopsis
  • YAP and TAZ are crucial coactivators often overactive in cancer, promoting tumor growth and resistance to treatments.
  • Niflumic acid (NA), a known inhibitor of YAP/TAZ, has poor effectiveness due to its short half-life, prompting the development of NA-based prodrug polymers to improve its bioavailability.
  • The selected NA polymer formed micellar nanocarriers that effectively targeted tumors and worked alongside receptor tyrosine kinase inhibitors (RTKIs) like Dasatinib, enhancing breast cancer therapy outcomes.
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Quiescent cells require a continuous supply of proteins to maintain protein homeostasis. In fission yeast, entry into quiescence is triggered by nitrogen stress, leading to the inactivation of TORC1 and the activation of TORC2. In this study, we demonstrate that the Greatwall-Endosulfine-PPA/B55 pathway connects the downregulation of TORC1 with the upregulation of TORC2, resulting in the activation of Elongator-dependent tRNA modifications crucial for sustaining the translation programme during entry into quiescence.

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Spinal cord injury (SCI) results in severe neurological deficits due to disrupted neural pathways. While the spinal cord possesses limited self-repair capabilities, recent advancements in hydrogel-based therapies have shown promise. Polyphenol-based hydrogels, known for their neuroprotective properties, offer a suitable microenvironment for neural regeneration.

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Wheat stripe rust, caused by f. sp. (), is a globally significant fungal disease that seriously threatens wheat yield, particularly in China.

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  • A novel single-component natural bioink was developed by modifying natural fucoidan, achieving both high mechanical strength and multiple biofunctionalities suitable for 3D bioprinting.
  • The bioink displayed significant mechanical properties (compression modulus of 311 kPa) and impressive biofunctionalities, including high antimicrobial (95.5% against E. coli) and antioxidant (94.7% ROS inhibition) effects.
  • In vivo tests demonstrated its effectiveness in cartilage repair, indicating promising potential for tissue and organ regeneration using this advanced 3D bioprinting material.
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  • The study aimed to understand how sennoside A behaves in the body after being administered either through injection or orally, using a validated liquid chromatography method for accurate measurement in rat plasma.
  • The method demonstrated strong reliability with a wide range for measurement accuracy and confirmed that sennoside A remains stable during the testing process.
  • Results showed that after oral administration in rats, sennoside A reaches peak concentration in about 2.9-3.6 hours, has a slow elimination rate, and exhibits low absolute bioavailability at just 0.9%-1.3%.
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Carrageenan oligosaccharides have shown promising bioavailability and possess a variety of physiological activities, making them highly suitable for use in the food, pharmaceutical, and agricultural industries. The preferred method for producing carrageenan oligosaccharides is using various carrageenolytic enzymes, as it offers mild reaction conditions, high efficiency, and product specificity. However, there is still a lack of specific applications for using these enzymes to prepare odd-numbered carrageenan-oligosaccharides (OCOSs).

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  • Researchers used NADPH-d to study neurodegeneration in aged monkeys, building on previous findings in aged rats and dogs.
  • They identified two abnormal NADPH-d positive structures: aging-related NADPH-d positive bodies (ANBs) and megaloneurites, primarily found in specific regions of the sacral spinal cord.
  • The study concluded that these two alterations serve as potential markers for aging in the pelvic visceral organs of non-human primates, with megaloneurites showing a connection to vasoactive intestinal peptide.
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  • Inhibiting secondary cell death and promoting neuronal regeneration is crucial for repairing spinal cord injuries (SCI), as excessive reactive oxygen species (ROS) contribute to nerve damage and cell death.
  • The study developed a nanozyme hydrogel delivery system called LA/Me/Se NPs-h, which effectively stabilizes and enhances the bioavailability of therapeutic drugs against oxidative stress following SCI.
  • Results from mouse models showed that LA/Me/Se NPs-h significantly improved locomotor function and reduced neuronal damage by increasing antioxidant enzyme activity and decreasing neuronal apoptosis, highlighting its potential as a treatment for SCI and related disorders.
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  • Chemodynamic therapy (CDT) is being explored as a new cancer treatment method that generates harmful reactive oxygen species (ROS) through metal ion catalysis, but reducing agents in tumors limit its effectiveness.
  • The study introduces a novel nano-delivery system (MNZ) that uses hollow manganese dioxide nanoparticles modified with copper ions, designed to first consume these reducing agents before applying CDT, enhancing overall treatment efficacy.
  • Experiments show that MNZ significantly reduces the viability of HeLa cancer cells, with the best effects when combined with heat (NIR), suggesting a promising approach for combined photothermal and chemodynamic therapies.
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The trigger generator made with a spiral generator (SG) has the advantages of light weight, compact structure, and low cost and has promising applications in the pulsed power field. This paper introduces a compact solid-state high-voltage pulse trigger system based on an improved SG, which has improved repetition rate and lowered the demands for semiconductor switches' maximum current and current rise rate when compared with previous studies. The improvement is achieved by winding outward an additional layer of the passive layer and low-voltage metal strip, which realizes a significant reduction of the peak current and current rise rate of the discharge switch.

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  • The study investigates the rare occurrence of malignant transformation in craniofacial fibrous dysplasia (FD), analyzing 305 patients over 18 years.
  • Out of these, 15 cases (4.9%) involved malignant changes, predominantly affecting females, with ages at diagnosis and transformation averaging 28.87 and 38.53 years, respectively.
  • The most common malignancy was osteosarcoma, and overall survival rates were low, with only 33.3% and 20% surviving at 3 and 5 years.
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  • - Histamine plays a key role in various bodily functions like allergic reactions, wakefulness, and gastric acid secretion, and it works through four different histamine receptors.
  • - The study analyzes 9 cryo-electron microscopy structures of these receptors bound to different G protein types and agonists, revealing important details about how histamine binds and the nuanced differences in receptor interactions.
  • - Findings include specific motifs for ligand recognition and key residues for selectivity, providing a framework for designing targeted drugs that can effectively interact with these histamine receptors.
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