Characterisation and sequencing of the novel phage Abp95, which is effective against multi-genotypes of carbapenem-resistant Acinetobacter baumannii.

Acinetobacter baumannii has become one of the most challenging conditional pathogens in health facilities. It causes various infectious diseases in humans, such as wound or urinary tract infections and pneumonia. Phage therapy has been used as an alternative strategy for antibiotic-resistant A.

Ambiphilic Behavior of Ge(II)-Pseudohalides in Inter- and Intramolecular Frustrated Lewis Pair Alkyne Addition Reactions.

The reaction of the germylene chloride (NacNac)GeCl (, NacNac = CH{(CMe)(2,6-PrCHN)}), phenylacetylene, and B(CF) gives the intermolecular frustrated Lewis pair (FLP) addition product . In this case, the Ge(II) center acts as a base. In contrast, the analogous reaction of germylene thiocyanate reacts independently with B(CF) to give the germylene cation salt [(NacNac)Ge][SCNB(CF)] .

The Varied Frustrated Lewis Pair Reactivity of the Germylene Phosphaketene (CH{(CMe)(2,6- Pr C H N)} )GePCO.

The germylene species (CH{(CMe)(2,6-iPr C H N)} )GePCO 1 is shown to react with the Lewis acids (E(C F ) E=B, Al). Nonetheless, 1 participates in FLP chemistry with electron deficient alkynes or olefins, acting as an intramolecular FLP. In contrast, in the presence of B(C F ) and an electron rich alkyne, 1 behaves as Ge-based nucleophile to effect intermolecular FLP addition to the alkyne.

Corrigendum: Isolation and Characterization of a Novel Myophage Abp9 Against Pandrug Resistant .

[This corrects the article DOI: 10.3389/fmicb.2020.

Isolation and Characterization of a Novel Myophage Abp9 Against Pandrug Resistant .

has emerged as one of the most troublesome pathogens in health care institutions. can cause a wide range of diseases in humans, including pneumonia and septicemia. Phage therapy has drawn great interest from medical researchers as a potential way to control infections by antibiotic-resistant .

A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity.

Flurbiprofen, a hydrophobic COX inhibitor, was coordinated axially with oxoplatin to form a new conjugate, cis, cis, trans-[Pt(IV)(NH)Cl(flurbiprofen)]. The successful synthesis of this new conjugate was confirmed by H, C, and Pt NMR. The potential of this conjugate being reduced to cisplatin and subsequently exerting its DNA cross-linking ability was verified using cyclic voltammetry (CV), HPLC, and mass spectrometry (MS).

Overcoming resistance to cisplatin by inhibition of glutathione S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo.

Platinum-based DNA-adducting agents are used extensively in the clinic for cancer chemotherapy. However, the anti-tumor efficacy of these drugs is severely limited by cisplatin resistance, and this can lead to the failure of chemotherapy. One of cisplatin resistance mechanisms is associated with overexpression of glutathione S-transferases (GSTs), which would accelerate the deactivation of cisplatin and decrease its antitumor efficiency.